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8qkb
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8qkb is ON HOLD Authors: Falke, S., Lieske, J., Guenther, S., Reinke, P.Y.A., Ewert, W., Loboda, J., Karnicar, K., Usenik, A., Lindic, N., Sekirnik,...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human cathepsin L in complex with the vinyl sulfone inhibitor K777== | |
| - | + | <StructureSection load='8qkb' size='340' side='right'caption='[[8qkb]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8qkb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QKB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D1R:NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE'>D1R</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qkb OCA], [https://pdbe.org/8qkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qkb RCSB], [https://www.ebi.ac.uk/pdbsum/8qkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qkb ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Ewert | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Karnicar | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chapman HN]] |
| - | [[Category: Meents | + | [[Category: Ewert W]] |
| - | [[Category: | + | [[Category: Falke S]] |
| - | [[Category: | + | [[Category: Guenther S]] |
| - | [[Category: | + | [[Category: Hinrichs W]] |
| - | [[Category: | + | [[Category: Karnicar K]] |
| + | [[Category: Lieske J]] | ||
| + | [[Category: Lindic N]] | ||
| + | [[Category: Loboda J]] | ||
| + | [[Category: Meents A]] | ||
| + | [[Category: Reinke PYA]] | ||
| + | [[Category: Sekirnik A]] | ||
| + | [[Category: Turk D]] | ||
| + | [[Category: Usenik A]] | ||
Current revision
Crystal structure of human cathepsin L in complex with the vinyl sulfone inhibitor K777
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Categories: Homo sapiens | Large Structures | Chapman HN | Ewert W | Falke S | Guenther S | Hinrichs W | Karnicar K | Lieske J | Lindic N | Loboda J | Meents A | Reinke PYA | Sekirnik A | Turk D | Usenik A
