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4p0l

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==Crystal Structure of Double Loop-Swapped Interleukin-36Ra With Additional Point Mutations==
==Crystal Structure of Double Loop-Swapped Interleukin-36Ra With Additional Point Mutations==
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<StructureSection load='4p0l' size='340' side='right' caption='[[4p0l]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='4p0l' size='340' side='right'caption='[[4p0l]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4p0l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P0L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4p0l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P0L FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p0j|4p0j]], [[4p0k|4p0k]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0l OCA], [http://pdbe.org/4p0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p0l RCSB], [http://www.ebi.ac.uk/pdbsum/4p0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0l ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p0l OCA], [https://pdbe.org/4p0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p0l RCSB], [https://www.ebi.ac.uk/pdbsum/4p0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p0l ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN]] Acrodermatitis continua suppurativa of Hallopeau;Generalized pustular psoriasis;Pustulosis palmaris et plantaris. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN] Acrodermatitis continua suppurativa of Hallopeau;Generalized pustular psoriasis;Pustulosis palmaris et plantaris. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN]] Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
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[https://www.uniprot.org/uniprot/IL36G_HUMAN IL36G_HUMAN] Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.[https://www.uniprot.org/uniprot/I36RA_HUMAN I36RA_HUMAN] Is a highly and a specific antagonist of the IL-1 receptor-related protein 2/IL1RL2-mediated response to interleukin IL36G. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4p0l" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4p0l" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Interleukin receptor antagonist|Interleukin receptor antagonist]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Guenther, S]]
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[[Category: Large Structures]]
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[[Category: Sundberg, E J]]
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[[Category: Guenther S]]
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[[Category: Chimera protein]]
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[[Category: Sundberg EJ]]
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[[Category: Cytokine]]
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[[Category: Interleukin]]
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Current revision

Crystal Structure of Double Loop-Swapped Interleukin-36Ra With Additional Point Mutations

PDB ID 4p0l

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