4pie

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==Crystal structure of human adenovirus 2 protease a substrate based nitrile inhibitor==
==Crystal structure of human adenovirus 2 protease a substrate based nitrile inhibitor==
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<StructureSection load='4pie' size='340' side='right' caption='[[4pie]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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<StructureSection load='4pie' size='340' side='right'caption='[[4pie]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pie]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PIE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pie]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PIE FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FO:N-{(2S)-2-(3-CHLOROPHENYL)-2-[(METHYLSULFONYL)AMINO]ACETYL}-L-PHENYLALANYL-N-[(2Z)-2-IMINOETHYL]GLYCINAMIDE'>3FO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4piq|4piq]], [[4pis|4pis]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3FO:N-{(2S)-2-(3-CHLOROPHENYL)-2-[(METHYLSULFONYL)AMINO]ACETYL}-L-PHENYLALANYL-N-[(2Z)-2-IMINOETHYL]GLYCINAMIDE'>3FO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenain Adenain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.39 3.4.22.39] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pie OCA], [https://pdbe.org/4pie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pie RCSB], [https://www.ebi.ac.uk/pdbsum/4pie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pie ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pie OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pie RCSB], [http://www.ebi.ac.uk/pdbsum/4pie PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRO_ADE02 PRO_ADE02] Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions. Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors. Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating. Without maturation, the particle lacks infectivity and is unable to uncoat. Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction. Cleaves host cells cytoskeletal keratins K7 and K18.<ref>PMID:22791715</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4pie" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenain]]
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[[Category: Human adenovirus 2]]
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[[Category: Altmann, E.]]
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[[Category: Large Structures]]
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[[Category: Bernardi, A.]]
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[[Category: Altmann E]]
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[[Category: Combrink, C.]]
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[[Category: Bernardi A]]
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[[Category: Ellis, D.]]
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[[Category: Combrink C]]
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[[Category: Erbel, C.]]
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[[Category: Ellis D]]
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[[Category: Grosche, P.]]
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[[Category: Erbel C]]
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[[Category: Hughes, N.]]
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[[Category: Grosche P]]
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[[Category: Jarousse, N.]]
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[[Category: Hughes N]]
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[[Category: Melkko, S.]]
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[[Category: Jarousse N]]
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[[Category: Ramage, P.]]
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[[Category: Mac Sweeney A]]
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[[Category: Sirockin, F.]]
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[[Category: Melkko S]]
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[[Category: Sweeney, A Mac.]]
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[[Category: Ramage P]]
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[[Category: Adenain]]
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[[Category: Sirockin F]]
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[[Category: Adenovirus]]
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[[Category: Cofactor]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Pvic]]
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Current revision

Crystal structure of human adenovirus 2 protease a substrate based nitrile inhibitor

PDB ID 4pie

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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