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4tt4

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Current revision (07:22, 27 September 2023) (edit) (undo)
 
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<StructureSection load='4tt4' size='340' side='right'caption='[[4tt4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4tt4' size='340' side='right'caption='[[4tt4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tt4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TT4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4tt2|4tt2]], [[4tt6|4tt6]], [[4tte|4tte]], [[4tu4|4tu4]], [[4tu6|4tu6]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATAD2, L16, PRO2000 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [https://pdbe.org/4tt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tt4 OCA], [https://pdbe.org/4tt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tt4 RCSB], [https://www.ebi.ac.uk/pdbsum/4tt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tt4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN]] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
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[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenosinetriphosphatase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Andersen, J]]
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[[Category: Andersen J]]
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[[Category: Bardenhagen, J]]
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[[Category: Bardenhagen J]]
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[[Category: Cardozo, M]]
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[[Category: Cardozo M]]
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[[Category: Do, M Geck]]
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[[Category: Geck Do M]]
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[[Category: Jones, P]]
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[[Category: Jones P]]
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[[Category: Ladbury, J]]
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[[Category: Ladbury J]]
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[[Category: Lee, G]]
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[[Category: Lee G]]
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[[Category: Leo, E]]
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[[Category: Leo E]]
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[[Category: Leonard, P]]
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[[Category: Leonard P]]
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[[Category: Palmer, W]]
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[[Category: Palmer W]]
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[[Category: Petrocchi, A]]
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[[Category: Petrocchi A]]
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[[Category: Poncet-Montange, G]]
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[[Category: Poncet-Montange G]]
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[[Category: Shi, X]]
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[[Category: Shi X]]
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[[Category: Zhan, Y]]
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[[Category: Zhan Y]]
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[[Category: Bromodomain-acetylated histone complex]]
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[[Category: Gene regulation]]
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Current revision

Crystal structure of ATAD2A bromodomain complexed with H3(1-21)K14Ac peptide

PDB ID 4tt4

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