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4txn

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==Crystal structure of uridine phosphorylase from Schistosoma mansoni in complex with 5-fluorouracil==
==Crystal structure of uridine phosphorylase from Schistosoma mansoni in complex with 5-fluorouracil==
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<StructureSection load='4txn' size='340' side='right' caption='[[4txn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4txn' size='340' side='right'caption='[[4txn]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4txn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4txn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_mansoni Schistosoma mansoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TXN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URF:5-FLUOROURACIL'>URF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4txh|4txh]], [[4txj|4txj]], [[4txl|4txl]], [[4txm|4txm]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URF:5-FLUOROURACIL'>URF</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_phosphorylase Uridine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.3 2.4.2.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4txn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txn OCA], [https://pdbe.org/4txn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4txn RCSB], [https://www.ebi.ac.uk/pdbsum/4txn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4txn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txn OCA], [http://pdbe.org/4txn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4txn RCSB], [http://www.ebi.ac.uk/pdbsum/4txn PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UPPA_SCHMA UPPA_SCHMA] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:26898674). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable).<ref>PMID:26898674</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4txn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4txn" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Uridine phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Brandao-Neto, J]]
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[[Category: Schistosoma mansoni]]
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[[Category: Cassago, A]]
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[[Category: Brandao-Neto J]]
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[[Category: DeMarco, R]]
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[[Category: Cassago A]]
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[[Category: Marinho, A]]
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[[Category: DeMarco R]]
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[[Category: Pereira, H M]]
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[[Category: Marinho A]]
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[[Category: Romanello, L]]
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[[Category: Pereira HM]]
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[[Category: Torini, J]]
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[[Category: Romanello L]]
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[[Category: Transferase]]
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[[Category: Torini J]]

Current revision

Crystal structure of uridine phosphorylase from Schistosoma mansoni in complex with 5-fluorouracil

PDB ID 4txn

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