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4uaz

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==DNA polymerase beta reactant complex with a templating adenine and incoming 8-oxodGTP, 20 s==
==DNA polymerase beta reactant complex with a templating adenine and incoming 8-oxodGTP, 20 s==
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<StructureSection load='4uaz' size='340' side='right' caption='[[4uaz]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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<StructureSection load='4uaz' size='340' side='right'caption='[[4uaz]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uaz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UAZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uaz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UAZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8DG:8-OXO-2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>8DG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8DG:8-OXO-2-DEOXYGUANOSINE-5-TRIPHOSPHATE'>8DG</scene>, <scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uaw|4uaw]], [[4uay|4uay]], [[4ub1|4ub1]], [[4ub2|4ub2]], [[4ub3|4ub3]], [[4ub4|4ub4]], [[4ub5|4ub5]], [[4ubb|4ubb]], [[4ubc|4ubc]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uaz OCA], [https://pdbe.org/4uaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uaz RCSB], [https://www.ebi.ac.uk/pdbsum/4uaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uaz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uaz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uaz RCSB], [http://www.ebi.ac.uk/pdbsum/4uaz PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4uaz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beard, W A]]
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[[Category: Homo sapiens]]
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[[Category: Freudenthal, B D]]
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[[Category: Large Structures]]
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[[Category: Wilson, S H]]
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[[Category: Synthetic construct]]
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[[Category: Dna polymerase]]
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[[Category: Beard WA]]
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[[Category: Lyase-dna complex]]
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[[Category: Freudenthal BD]]
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[[Category: Transferase]]
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[[Category: Wilson SH]]

Current revision

DNA polymerase beta reactant complex with a templating adenine and incoming 8-oxodGTP, 20 s

PDB ID 4uaz

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