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4yqu

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==Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-31==
==Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-31==
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<StructureSection load='4yqu' size='340' side='right' caption='[[4yqu]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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<StructureSection load='4yqu' size='340' side='right'caption='[[4yqu]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yqu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YQU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YQU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4GB:N-{5-(AZEPAN-1-YLSULFONYL)-2-[(ETHYLSULFANYL)METHOXY]PHENYL}ACETAMIDE'>4GB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yqm|4yqm]], [[4yqv|4yqv]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4GB:N-{5-(AZEPAN-1-YLSULFONYL)-2-[(ETHYLSULFANYL)METHOXY]PHENYL}ACETAMIDE'>4GB</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqu OCA], [http://pdbe.org/4yqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yqu RCSB], [http://www.ebi.ac.uk/pdbsum/4yqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqu OCA], [https://pdbe.org/4yqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yqu RCSB], [https://www.ebi.ac.uk/pdbsum/4yqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN]] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>
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[https://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4yqu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4yqu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Stuckey, J A]]
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[[Category: Homo sapiens]]
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[[Category: Chloroacetamide]]
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[[Category: Large Structures]]
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[[Category: Covalent inhibitor]]
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[[Category: Stuckey JA]]
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[[Category: Thioltransferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Glutathione S-transferase Omega 1 bound to covalent inhibitor C1-31

PDB ID 4yqu

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