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4zh3

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==Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br==
==Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br==
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<StructureSection load='4zh3' size='340' side='right' caption='[[4zh3]], [[Resolution|resolution]] 4.08&Aring;' scene=''>
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<StructureSection load='4zh3' size='340' side='right'caption='[[4zh3]], [[Resolution|resolution]] 4.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zh3]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZH3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZH3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zh3]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZH3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4OD:N-(3-BROMOPHENYL)-4-FLUORO-N-HYDROXY-3-(TRIFLUOROMETHYL)BENZENECARBOXIMIDAMIDE'>4OD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.082&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zh2|4zh2]], [[4zh4|4zh4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4OD:N-(3-BROMOPHENYL)-4-FLUORO-N-HYDROXY-3-(TRIFLUOROMETHYL)BENZENECARBOXIMIDAMIDE'>4OD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zh3 OCA], [https://pdbe.org/4zh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zh3 RCSB], [https://www.ebi.ac.uk/pdbsum/4zh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zh3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zh3 OCA], [http://pdbe.org/4zh3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zh3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zh3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zh3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RPOZ_ECOLI RPOZ_ECOLI]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.[HAMAP-Rule:MF_00366] [[http://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059] [[http://www.uniprot.org/uniprot/RPOC_ECOLI RPOC_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01322] [[http://www.uniprot.org/uniprot/RPOB_ECOLI RPOB_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321] [[http://www.uniprot.org/uniprot/RPOD_ECOLI RPOD_ECOLI]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This is the primary sigma factor of this bacterium.
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[https://www.uniprot.org/uniprot/RPOC_ECOLI RPOC_ECOLI] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01322]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zh3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zh3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Ebright, R H]]
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[[Category: Large Structures]]
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[[Category: Feng, Y]]
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[[Category: Ebright RH]]
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[[Category: Inhibitor]]
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[[Category: Feng Y]]
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[[Category: Rna polymerase]]
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[[Category: Transcription]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br

PDB ID 4zh3

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