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4zk4
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4zk4 is ON HOLD Authors: Bobango, J., Wu, J., Talley, T.T. Description: Crystal structure of a chimeric acetylcholine binding protein from Aplysia ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy-pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane== | |
| + | <StructureSection load='4zk4' size='340' side='right'caption='[[4zk4]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4zk4]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZK4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TII:(5R)-1-METHYL-7-[5-(PROPAN-2-YLOXY)PYRIDIN-3-YL]-1,7-DIAZASPIRO[4.4]NONANE'>TII</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk4 OCA], [https://pdbe.org/4zk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zk4 RCSB], [https://www.ebi.ac.uk/pdbsum/4zk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACHA3_HUMAN ACHA3_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA] | ||
| - | + | ==See Also== | |
| - | + | *[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Aplysia californica]] |
| - | [[Category: Bobango | + | [[Category: Homo sapiens]] |
| - | [[Category: Wu | + | [[Category: Large Structures]] |
| + | [[Category: Bobango J]] | ||
| + | [[Category: Talley TT]] | ||
| + | [[Category: Wu J]] | ||
Current revision
Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy-pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane
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