This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4zoj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:21, 27 September 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
==Methylsulfanyl-containing inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)==
==Methylsulfanyl-containing inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)==
-
<StructureSection load='4zoj' size='340' side='right' caption='[[4zoj]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
+
<StructureSection load='4zoj' size='340' side='right'caption='[[4zoj]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4zoj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZOJ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4zoj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Ra Mycobacterium tuberculosis H37Ra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZOJ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=61L:4-METHYL-2-{[2-METHYL-6-(METHYLSULFANYL)PHENYL]AMINO}BENZOIC+ACID'>61L</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4giu|4giu]], [[3qr9|3qr9]], [[4zof|4zof]], [[4zok|4zok]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=61L:4-METHYL-2-{[2-METHYL-6-(METHYLSULFANYL)PHENYL]AMINO}BENZOIC+ACID'>61L</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PRP:ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC+ACID'>PRP</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anthranilate_phosphoribosyltransferase Anthranilate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.18 2.4.2.18] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zoj OCA], [https://pdbe.org/4zoj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zoj RCSB], [https://www.ebi.ac.uk/pdbsum/4zoj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zoj ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zoj OCA], [http://pdbe.org/4zoj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zoj RCSB], [http://www.ebi.ac.uk/pdbsum/4zoj PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TRPD_MYCTA TRPD_MYCTA]] Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
+
[https://www.uniprot.org/uniprot/TRPD_MYCTA TRPD_MYCTA] Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
 +
 
 +
==See Also==
 +
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Anthranilate phosphoribosyltransferase]]
+
[[Category: Large Structures]]
-
[[Category: Baker, E N]]
+
[[Category: Mycobacterium tuberculosis H37Ra]]
-
[[Category: Evans, G L]]
+
[[Category: Baker EN]]
-
[[Category: Lott, J S]]
+
[[Category: Evans GL]]
-
[[Category: Structural genomic]]
+
[[Category: Lott JS]]
-
[[Category: Complex]]
+
-
[[Category: Inhibitor]]
+
-
[[Category: Lobenzarit-like analogue]]
+
-
[[Category: Magnesium binding]]
+
-
[[Category: Phosphoribosylpyrophosphate]]
+
-
[[Category: Phosphoribosyltransferase]]
+
-
[[Category: Prpp]]
+
-
[[Category: Tbsgc]]
+
-
[[Category: Transferase-transferase inhibitor complex]]
+

Current revision

Methylsulfanyl-containing inhibitor bound in the active site of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)

PDB ID 4zoj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4zoj"
Personal tools