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4zw6

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<StructureSection load='4zw6' size='340' side='right'caption='[[4zw6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4zw6' size='340' side='right'caption='[[4zw6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zw6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafq Plafq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZW6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FcB1/Columbia Plasmodium falciparum FcB1/Columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZW6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4SY:TERT-BUTYL+{(1S)-2-(HYDROXYAMINO)-1-[4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL]-2-OXOETHYL}CARBAMATE'>4SY</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ebg|3ebg]], [[4zw3|4zw3]], [[4zw5|4zw5]], [[4zw7|4zw7]], [[4zw8|4zw8]], [[4zx3|4zx3]], [[4zx4|4zx4]], [[4zx5|4zx5]], [[4zx6|4zx6]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4SY:TERT-BUTYL+{(1S)-2-(HYDROXYAMINO)-1-[4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL]-2-OXOETHYL}CARBAMATE'>4SY</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zw6 OCA], [http://pdbe.org/4zw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zw6 RCSB], [http://www.ebi.ac.uk/pdbsum/4zw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zw6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zw6 OCA], [https://pdbe.org/4zw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zw6 RCSB], [https://www.ebi.ac.uk/pdbsum/4zw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zw6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ]] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
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[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Plafq]]
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[[Category: Plasmodium falciparum FcB1/Columbia]]
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[[Category: Drinkwater, N]]
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[[Category: Drinkwater N]]
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[[Category: McGowan, S]]
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[[Category: McGowan S]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Hydroxamic acid]]
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[[Category: Inhibitor]]
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[[Category: M1 alanyl-aminopeptidase]]
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[[Category: Protease]]
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Current revision

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 9q

PDB ID 4zw6

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