5c8h
From Proteopedia
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==Crystal structure of ORC2 C-terminal domain== | ==Crystal structure of ORC2 C-terminal domain== | ||
| - | <StructureSection load='5c8h' size='340' side='right' caption='[[5c8h]], [[Resolution|resolution]] 2.01Å' scene=''> | + | <StructureSection load='5c8h' size='340' side='right'caption='[[5c8h]], [[Resolution|resolution]] 2.01Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5c8h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C8H OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5c8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C8H FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c8h OCA], [https://pdbe.org/5c8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c8h RCSB], [https://www.ebi.ac.uk/pdbsum/5c8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c8h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ORC2_HUMAN ORC2_HUMAN] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.<ref>PMID:22427655</ref> <ref>PMID:22935713</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Arrowsmith | + | [[Category: Homo sapiens]] |
| - | [[Category: Bountra | + | [[Category: Large Structures]] |
| - | [[Category: Dong | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Edwards | + | [[Category: Bountra C]] |
| - | [[Category: Loppnau | + | [[Category: Dong A]] |
| - | [[Category: Min | + | [[Category: Edwards AM]] |
| - | + | [[Category: Loppnau P]] | |
| - | [[Category: Tempel | + | [[Category: Min J]] |
| - | [[Category: Xu | + | [[Category: Tempel W]] |
| - | + | [[Category: Xu C]] | |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of ORC2 C-terminal domain
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Dong A | Edwards AM | Loppnau P | Min J | Tempel W | Xu C
