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5c9h

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==Structural Basis of Template Boundary Definition in Tetrahymena Telomerase==
==Structural Basis of Template Boundary Definition in Tetrahymena Telomerase==
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<StructureSection load='5c9h' size='340' side='right' caption='[[5c9h]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='5c9h' size='340' side='right'caption='[[5c9h]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5c9h]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C9H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5c9h]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C9H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c9h OCA], [http://pdbe.org/5c9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c9h RCSB], [http://www.ebi.ac.uk/pdbsum/5c9h PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c9h OCA], [https://pdbe.org/5c9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c9h RCSB], [https://www.ebi.ac.uk/pdbsum/5c9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c9h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TERT_TETTH TERT_TETTH]] Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (By similarity).
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[https://www.uniprot.org/uniprot/TERT_TETTS TERT_TETTS] Catalytic component of telomerase, an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747). TERT is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747).<ref>PMID:10944124</ref> <ref>PMID:15696174</ref> <ref>PMID:16462747</ref> <ref>PMID:17322903</ref> <ref>PMID:20713447</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5c9h" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5c9h" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Telomerase 3D structures|Telomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: RNA-directed DNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Akiyama, B M]]
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[[Category: Tetrahymena thermophila]]
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[[Category: Jansson, L I]]
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[[Category: Akiyama BM]]
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[[Category: Lu, C]]
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[[Category: Jansson LI]]
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[[Category: Ooms, A]]
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[[Category: Lu C]]
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[[Category: Rubin, S M]]
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[[Category: Ooms A]]
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[[Category: Stone, M D]]
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[[Category: Rubin SM]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Stone MD]]
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[[Category: Rna-protein complex]]
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[[Category: Telomerase]]
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Current revision

Structural Basis of Template Boundary Definition in Tetrahymena Telomerase

PDB ID 5c9h

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