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5cci

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==Structure of the Mg2+-bound synaptotagmin-1 SNARE complex (short unit cell form)==
==Structure of the Mg2+-bound synaptotagmin-1 SNARE complex (short unit cell form)==
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<StructureSection load='5cci' size='340' side='right' caption='[[5cci]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
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<StructureSection load='5cci' size='340' side='right'caption='[[5cci]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5cci]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5cci]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ccg|5ccg]], [[5cch|5cch]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cci OCA], [http://pdbe.org/5cci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cci RCSB], [http://www.ebi.ac.uk/pdbsum/5cci PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cci OCA], [https://pdbe.org/5cci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cci RCSB], [https://www.ebi.ac.uk/pdbsum/5cci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cci ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. [[http://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT]] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). [[http://www.uniprot.org/uniprot/STX1A_RAT STX1A_RAT]] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. [[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
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[https://www.uniprot.org/uniprot/VAMP2_RAT VAMP2_RAT] Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5cci" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5cci" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Synaptosomal-associated protein|Synaptosomal-associated protein]]
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
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*[[Syntaxin 3D structures|Syntaxin 3D structures]]
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*[[Vesicle-associated membrane protein|Vesicle-associated membrane protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brunger, A T]]
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[[Category: Large Structures]]
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[[Category: Lyubimov, A Y]]
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[[Category: Rattus norvegicus]]
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[[Category: Uervirojnangkoorn, M]]
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[[Category: Brunger AT]]
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[[Category: Weis, W I]]
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[[Category: Lyubimov AY]]
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[[Category: Zhao, M]]
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[[Category: Uervirojnangkoorn M]]
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[[Category: Zhou, Q]]
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[[Category: Weis WI]]
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[[Category: Endocytosis]]
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[[Category: Zhao M]]
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[[Category: Exocytosis]]
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[[Category: Zhou Q]]
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[[Category: Neuronal snare complex]]
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[[Category: Synaptic fusion complex]]
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[[Category: Synaptotagmin1]]
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Current revision

Structure of the Mg2+-bound synaptotagmin-1 SNARE complex (short unit cell form)

PDB ID 5cci

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