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5ccj

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==Crystal structure of the quintuple mutant of the synaptotagmin-1 C2B domain==
==Crystal structure of the quintuple mutant of the synaptotagmin-1 C2B domain==
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<StructureSection load='5ccj' size='340' side='right' caption='[[5ccj]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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<StructureSection load='5ccj' size='340' side='right'caption='[[5ccj]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ccj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ccj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ccj RCSB], [http://www.ebi.ac.uk/pdbsum/5ccj PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ccj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccj OCA], [https://pdbe.org/5ccj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ccj RCSB], [https://www.ebi.ac.uk/pdbsum/5ccj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
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[https://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 5ccj" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brunger, A T]]
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[[Category: Large Structures]]
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[[Category: Zhao, M]]
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[[Category: Rattus norvegicus]]
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[[Category: Zhou, Q]]
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[[Category: Brunger AT]]
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[[Category: C2b domain]]
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[[Category: Zhao M]]
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[[Category: Signaling protein]]
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[[Category: Zhou Q]]
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[[Category: Synaptotagmin1]]
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Current revision

Crystal structure of the quintuple mutant of the synaptotagmin-1 C2B domain

PDB ID 5ccj

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