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5k4f

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==CAL PDZ mutant C319A with a peptide==
==CAL PDZ mutant C319A with a peptide==
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<StructureSection load='5k4f' size='340' side='right' caption='[[5k4f]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
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<StructureSection load='5k4f' size='340' side='right'caption='[[5k4f]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5k4f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K4F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K4F FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5k4f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K4F FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k4f OCA], [http://pdbe.org/5k4f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k4f RCSB], [http://www.ebi.ac.uk/pdbsum/5k4f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k4f ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k4f OCA], [https://pdbe.org/5k4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k4f RCSB], [https://www.ebi.ac.uk/pdbsum/5k4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k4f ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
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[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.<ref>PMID:12661006</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN]] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref> [[http://www.uniprot.org/uniprot/VE6_HPV18 VE6_HPV18]] Transcriptional transactivator. Binds double stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.
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[https://www.uniprot.org/uniprot/GOPC_HUMAN GOPC_HUMAN] Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.<ref>PMID:11707463</ref> <ref>PMID:14570915</ref> <ref>PMID:15358775</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Madden, D R]]
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[[Category: Homo sapiens]]
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[[Category: Zhao, Y]]
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[[Category: Human papillomavirus type 18]]
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[[Category: C319a]]
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[[Category: Large Structures]]
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[[Category: Cal pdz mutant]]
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[[Category: Madden DR]]
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[[Category: Peptide binding protein]]
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[[Category: Zhao Y]]

Current revision

CAL PDZ mutant C319A with a peptide

PDB ID 5k4f

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