This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5kdl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:58, 27 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS==
==Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS==
-
<StructureSection load='5kdl' size='340' side='right' caption='[[5kdl]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
+
<StructureSection load='5kdl' size='340' side='right'caption='[[5kdl]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5kdl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KDL FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5kdl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KDL FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.665&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kdo|5kdo]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kdl OCA], [http://pdbe.org/5kdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kdl RCSB], [http://www.ebi.ac.uk/pdbsum/5kdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kdl ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kdl OCA], [https://pdbe.org/5kdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kdl RCSB], [https://www.ebi.ac.uk/pdbsum/5kdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kdl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
+
[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Gilbert, J]]
+
[[Category: Large Structures]]
-
[[Category: Hamm, H E]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Iverson, T M]]
+
[[Category: Gilbert J]]
-
[[Category: Kaya, A I]]
+
[[Category: Hamm HE]]
-
[[Category: Lokits, A D]]
+
[[Category: Iverson TM]]
-
[[Category: Meiler, J]]
+
[[Category: Kaya AI]]
-
[[Category: Heterotrimeric g protein g protein coupled receptors g protein activation g protein structure gdp release]]
+
[[Category: Lokits AD]]
-
[[Category: Signaling protein]]
+
[[Category: Meiler J]]

Current revision

Crystal structure of the 4 alanine insertion variant of the Gi alpha1 subunit bound to GTPgammaS

PDB ID 5kdl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5kdl"
Personal tools