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5kdr

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Current revision (09:58, 27 September 2023) (edit) (undo)
 
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<StructureSection load='5kdr' size='340' side='right'caption='[[5kdr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5kdr' size='340' side='right'caption='[[5kdr]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kdr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staa3 Staa3] and [http://en.wikipedia.org/wiki/Staab Staab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KDR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KDR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kdr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_RF122 Staphylococcus aureus RF122] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_USA300 Staphylococcus aureus subsp. aureus USA300]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KDR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KDR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YT5:MOIRAMIDE+B'>YT5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f9i|2f9i]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YT5:MOIRAMIDE+B'>YT5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">accA, SAUSA300_1646 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=367830 STAA3]), accD, SAB1559c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273036 STAAB])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kdr OCA], [https://pdbe.org/5kdr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kdr RCSB], [https://www.ebi.ac.uk/pdbsum/5kdr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kdr ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_carboxylase Acetyl-CoA carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.2 6.4.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kdr OCA], [http://pdbe.org/5kdr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kdr RCSB], [http://www.ebi.ac.uk/pdbsum/5kdr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kdr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACCA_STAA3 ACCA_STAA3]] Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.[HAMAP-Rule:MF_00823] [[http://www.uniprot.org/uniprot/ACCD_STAAB ACCD_STAAB]] Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
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[https://www.uniprot.org/uniprot/ACCA_STAA8 ACCA_STAA8] Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.[HAMAP-Rule:MF_00823]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acetyl-CoA carboxylase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Staa3]]
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[[Category: Staphylococcus aureus RF122]]
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[[Category: Staab]]
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[[Category: Staphylococcus aureus subsp. aureus USA300]]
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[[Category: Anzalone, N]]
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[[Category: Anzalone N]]
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[[Category: Neau, D]]
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[[Category: Neau D]]
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[[Category: Pakhomova, S]]
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[[Category: Pakhomova S]]
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[[Category: Silvers, M A]]
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[[Category: Silvers MA]]
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[[Category: Silvers, W C]]
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[[Category: Silvers WC]]
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[[Category: Taylor, C M]]
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[[Category: Taylor CM]]
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[[Category: Waldrop, G L]]
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[[Category: Waldrop GL]]
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[[Category: Acetyl-coa carboxylase]]
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[[Category: Antibiotic]]
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[[Category: Carboxyltransferase]]
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[[Category: Enolate]]
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[[Category: Moiramide b]]
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[[Category: Transferase]]
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Current revision

The crystal structure of carboxyltransferase from Staphylococcus Aureus bound to the antimicrobial agent moiramide B.

PDB ID 5kdr

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