7x9d

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(New page: '''Unreleased structure''' The entry 7x9d is ON HOLD Authors: Cho, C.-C., Yuan, H.S. Description: DNMT3B in complex with harmine Category: Unreleased Structures [[Category: Cho, C....)
Current revision (10:05, 27 September 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7x9d is ON HOLD
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==DNMT3B in complex with harmine==
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<StructureSection load='7x9d' size='340' side='right'caption='[[7x9d]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
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Authors: Cho, C.-C., Yuan, H.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7x9d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X9D FirstGlance]. <br>
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Description: DNMT3B in complex with harmine
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.08&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HRM:7-METHOXY-1-METHYL-9H-BETA-CARBOLINE'>HRM</scene></td></tr>
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[[Category: Cho, C.-C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x9d OCA], [https://pdbe.org/7x9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x9d RCSB], [https://www.ebi.ac.uk/pdbsum/7x9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x9d ProSAT]</span></td></tr>
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[[Category: Yuan, H.S]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] ICF syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10647011</ref> <ref>PMID:10555141</ref> <ref>PMID:10588719</ref> <ref>PMID:11102980</ref> <ref>PMID:15580563</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.<ref>PMID:16357870</ref> <ref>PMID:17303076</ref> <ref>PMID:18413740</ref> <ref>PMID:18567530</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cho C-C]]
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[[Category: Yuan HS]]

Current revision

DNMT3B in complex with harmine

PDB ID 7x9d

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