This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1n47
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1n47.gif|left|200px]] | [[Image:1n47.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1n47", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1n47| PDB=1n47 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Isolectin B4 from Vicia villosa in complex with the Tn antigen''' | '''Isolectin B4 from Vicia villosa in complex with the Tn antigen''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N47 OCA]. | |
==Reference== | ==Reference== | ||
The crystal structure of a plant lectin in complex with the Tn antigen., Babino A, Tello D, Rojas A, Bay S, Osinaga E, Alzari PM, FEBS Lett. 2003 Feb 11;536(1-3):106-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12586347 12586347] | The crystal structure of a plant lectin in complex with the Tn antigen., Babino A, Tello D, Rojas A, Bay S, Osinaga E, Alzari PM, FEBS Lett. 2003 Feb 11;536(1-3):106-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12586347 12586347] | ||
| - | [[Category: Protein complex]] | ||
| - | [[Category: Vicia villosa]] | ||
[[Category: Alzari, P M.]] | [[Category: Alzari, P M.]] | ||
[[Category: Babino, A.]] | [[Category: Babino, A.]] | ||
| Line 31: | Line 26: | ||
[[Category: Rojas, A.]] | [[Category: Rojas, A.]] | ||
[[Category: Tello, D.]] | [[Category: Tello, D.]] | ||
| - | [[Category: | + | [[Category: Cancer antigen]] |
| - | [[Category: | + | [[Category: Carbohydrate recognition]] |
| - | [[Category: | + | [[Category: Glycoprotein tn-binding protein]] |
| - | [[Category: | + | [[Category: Vicia villosa lectin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:04:10 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 23:04, 2 May 2008
Isolectin B4 from Vicia villosa in complex with the Tn antigen
Overview
The structure of the tetrameric Vicia villosa isolectin B4 (VVLB4) in complex with a cancer antigen, the Tn glycopeptide (GalNAc-O-Ser), was determined at 2.7 A resolution. The N-acetylgalactoside moiety of the ligand binds to the primary combining site of VVLB4 in a similar way as observed for other Gal/GalNAc-specific plant lectins. The amino acid moiety of the Tn antigen is largely exposed to the solvent and makes few contacts with the protein. The structure of the complex provides a framework to understand the differences in the strength of VVLB4 binding to different sugars and emphasizes the role of a single protein residue, Tyr127, as a structural determinant of Tn-binding specificity.
About this Structure
Full crystallographic information is available from OCA.
Reference
The crystal structure of a plant lectin in complex with the Tn antigen., Babino A, Tello D, Rojas A, Bay S, Osinaga E, Alzari PM, FEBS Lett. 2003 Feb 11;536(1-3):106-10. PMID:12586347 Page seeded by OCA on Sat May 3 02:04:10 2008
