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5kt8

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==Crystal structure of the W139F variant of the catalase-peroxidase from B. pseudomallei treated with isoniazid==
==Crystal structure of the W139F variant of the catalase-peroxidase from B. pseudomallei treated with isoniazid==
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<StructureSection load='5kt8' size='340' side='right' caption='[[5kt8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5kt8' size='340' side='right'caption='[[5kt8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kt8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KT8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kt8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KT8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NIZ:PYRIDINE-4-CARBOHYDRAZIDE'>NIZ</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TOX:1-HYDROPEROXY-L-TRYPTOPHAN'>TOX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NIZ:PYRIDINE-4-CARBOHYDRAZIDE'>NIZ</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=TOX:1-HYDROPEROXY-L-TRYPTOPHAN'>TOX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kq0|5kq0]], [[5kq2|5kq2]], [[5kq3|5kq3]], [[5kq6|5kq6]], [[5kq7|5kq7]], [[5kqh|5kqh]], [[5kqi|5kqi]], [[5kqk|5kqk]], [[5kqn|5kqn]], [[5kqq|5kqq]], [[5ksf|5ksf]], [[5ksg|5ksg]], [[5ksk|5ksk]], [[5ksn|5ksn]], [[5kt9|5kt9]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kt8 OCA], [https://pdbe.org/5kt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kt8 RCSB], [https://www.ebi.ac.uk/pdbsum/5kt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kt8 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase_peroxidase Catalase peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.21 1.11.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kt8 OCA], [http://pdbe.org/5kt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kt8 RCSB], [http://www.ebi.ac.uk/pdbsum/5kt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kt8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KATG_BURP1 KATG_BURP1]] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
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[https://www.uniprot.org/uniprot/KATG_BURP1 KATG_BURP1] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
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==See Also==
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*[[Catalase 3D structures|Catalase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Catalase peroxidase]]
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[[Category: Burkholderia pseudomallei 1710b]]
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[[Category: Loewen, P C]]
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[[Category: Large Structures]]
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[[Category: Catalase]]
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[[Category: Loewen PC]]
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[[Category: Heme]]
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[[Category: Isoniazid]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxidase]]
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[[Category: W139f]]
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Current revision

Crystal structure of the W139F variant of the catalase-peroxidase from B. pseudomallei treated with isoniazid

PDB ID 5kt8

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