Pyruvate-ferredoxin oxidoreductase
From Proteopedia
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| - | <StructureSection load='2c3o' size=' | + | <StructureSection load='2c3o' size='350' side='right' scene='49/490113/Cv/1' caption='Pyruvate-ferredoxin oxidoredoxin dimer with Fe4S4 cluster complex with thiamine diphosphate and pyruvate [[2c3o]]'> |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The active site of PFOR contains thiamine diphosphate and pyruvate<ref>PMID:16472741</ref>. | + | The <scene name='49/490113/Cv/6'>active site of PFOR contains thiamine diphosphate and pyruvate</scene><ref>PMID:16472741</ref>. <scene name='49/490113/Cv/7'>Mg coordination site</scene>. Water molecules are shown as red spheres. <scene name='49/490113/Cv/8'>Fe4S4 cluster interactions</scene>. Each Fe atom interacts with S atom from cysteine. |
</StructureSection> | </StructureSection> | ||
==3D structures of pyruvate-ferredoxin oxidoreductase== | ==3D structures of pyruvate-ferredoxin oxidoreductase== | ||
| - | + | {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |
[[1b0p]], [[2c3m]] – DaPFOR + TDP – ''Desulfovibrio africanus''<br /> | [[1b0p]], [[2c3m]] – DaPFOR + TDP – ''Desulfovibrio africanus''<br /> | ||
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[[2c3p]] - DaPFOR + TDP derivative<br /> | [[2c3p]] - DaPFOR + TDP derivative<br /> | ||
[[2c3u]] - DaPFOR + pyruvate + TDP derivative<br /> | [[2c3u]] - DaPFOR + pyruvate + TDP derivative<br /> | ||
| - | [[2raa]] - PFOR γ subunit - ''Thermotoga maritima'' | + | [[7plm]] – DaPFOR + TPP – Cryo EM<br /> |
| + | [[2raa]] - PFOR γ subunit - ''Thermotoga maritima''<br /> | ||
| + | [[6cin]] – MtPFOR + TDP – ''Moorella thermoacetica''<br /> | ||
| + | [[6cio]], [[6cip]] – MtPFOR + TTP derivative <br /> | ||
| + | [[6ciq]] – MtPFOR + TTP + CoA <br /> | ||
Current revision
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3D structures of pyruvate-ferredoxin oxidoreductase
04-October-2023
1b0p, 2c3m – DaPFOR + TDP – Desulfovibrio africanus
2pda, 2c3o, 2c42 - DaPFOR + pyruvate + TDP
1kek, 2c3y, 2uza - DaPFOR + CO2 + acetyl-TDP
2c3p - DaPFOR + TDP derivative
2c3u - DaPFOR + pyruvate + TDP derivative
7plm – DaPFOR + TPP – Cryo EM
2raa - PFOR γ subunit - Thermotoga maritima
6cin – MtPFOR + TDP – Moorella thermoacetica
6cio, 6cip – MtPFOR + TTP derivative
6ciq – MtPFOR + TTP + CoA
References
- ↑ Furdui C, Ragsdale SW. The role of pyruvate ferredoxin oxidoreductase in pyruvate synthesis during autotrophic growth by the Wood-Ljungdahl pathway. J Biol Chem. 2000 Sep 15;275(37):28494-9. PMID:10878009 doi:http://dx.doi.org/10.1074/jbc.M003291200
- ↑ Cavazza C, Contreras-Martel C, Pieulle L, Chabriere E, Hatchikian EC, Fontecilla-Camps JC. Flexibility of thiamine diphosphate revealed by kinetic crystallographic studies of the reaction of pyruvate-ferredoxin oxidoreductase with pyruvate. Structure. 2006 Feb;14(2):217-24. PMID:16472741 doi:10.1016/j.str.2005.10.013
