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8gy5

From Proteopedia

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Current revision (12:33, 4 October 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8gy5 is ON HOLD until Paper Publication
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==High-resolution structure of the cemiplimab Fab in complex with PD-1==
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<StructureSection load='8gy5' size='340' side='right'caption='[[8gy5]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
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Authors: Heo, Y.-S., Jeong, T.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8gy5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GY5 FirstGlance]. <br>
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Description: High-resolution structure of the cemiplimab Fab in complex with PD-1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gy5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gy5 OCA], [https://pdbe.org/8gy5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gy5 RCSB], [https://www.ebi.ac.uk/pdbsum/8gy5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gy5 ProSAT]</span></td></tr>
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[[Category: Jeong, T.J]]
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</table>
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[[Category: Heo, Y.-S]]
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== Disease ==
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[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN] Systemic lupus erythematosus;Multiple sclerosis. Systemic lupus erythematosus 2 (SLEB2) [MIM:[https://omim.org/entry/605218 605218]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.<ref>PMID:12402038</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PDCD1_HUMAN PDCD1_HUMAN] Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.<ref>PMID:21276005</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Heo Y-S]]
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[[Category: Jeong TJ]]

Current revision

High-resolution structure of the cemiplimab Fab in complex with PD-1

PDB ID 8gy5

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