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5l11

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==Human Liver Receptor Homologue-1 (LRH-1) Bound to RJW100 and a Fragment of TIF-2==
==Human Liver Receptor Homologue-1 (LRH-1) Bound to RJW100 and a Fragment of TIF-2==
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<StructureSection load='5l11' size='340' side='right' caption='[[5l11]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='5l11' size='340' side='right'caption='[[5l11]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l11]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L11 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L11 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RJW:(1R,3AR,6AR)-5-HEXYL-4-PHENYL-3A-(1-PHENYLETHENYL)-1,2,3,3A,6,6A-HEXAHYDROPENTALEN-1-OL'>RJW</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.849&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l11 OCA], [http://pdbe.org/5l11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l11 RCSB], [http://www.ebi.ac.uk/pdbsum/5l11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l11 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RJW:(1R,3AR,6AR)-5-HEXYL-4-PHENYL-3A-(1-PHENYLETHENYL)-1,2,3,3A,6,6A-HEXAHYDROPENTALEN-1-OL'>RJW</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l11 OCA], [https://pdbe.org/5l11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l11 RCSB], [https://www.ebi.ac.uk/pdbsum/5l11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l11 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
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[https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5l11" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5l11" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Liver receptor homolog-1|Liver receptor homolog-1]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mays, S G]]
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[[Category: Homo sapiens]]
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[[Category: Ortlund, E A]]
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[[Category: Large Structures]]
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[[Category: Agonist]]
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[[Category: Mays SG]]
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[[Category: Nuclear receptor]]
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[[Category: Ortlund EA]]
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[[Category: Transcription-inhibitor complex]]
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Current revision

Human Liver Receptor Homologue-1 (LRH-1) Bound to RJW100 and a Fragment of TIF-2

PDB ID 5l11

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