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5svz

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Current revision (12:48, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5svz' size='340' side='right'caption='[[5svz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5svz' size='340' side='right'caption='[[5svz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5svz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5SVZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5svz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5SVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5SVZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5svz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5svz OCA], [http://pdbe.org/5svz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5svz RCSB], [http://www.ebi.ac.uk/pdbsum/5svz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5svz ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5svz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5svz OCA], [https://pdbe.org/5svz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5svz RCSB], [https://www.ebi.ac.uk/pdbsum/5svz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5svz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
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[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Forwood, J K]]
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[[Category: Mus musculus]]
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[[Category: Himiari, Z]]
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[[Category: Forwood JK]]
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[[Category: Smith, K M]]
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[[Category: Himiari Z]]
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[[Category: Complex]]
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[[Category: Smith KM]]
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[[Category: Hiv-1]]
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[[Category: Importin alpha]]
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[[Category: Tat]]
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[[Category: Transport protein-viral protein complex]]
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[[Category: Virus]]
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Current revision

HIV-1 Tat NLS in complex with importin alpha

PDB ID 5svz

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