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5t7x

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Current revision (12:56, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5t7x' size='340' side='right'caption='[[5t7x]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='5t7x' size='340' side='right'caption='[[5t7x]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5t7x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T7X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5T7X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5t7x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T7X FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5t7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t7x OCA], [http://pdbe.org/5t7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t7x RCSB], [http://www.ebi.ac.uk/pdbsum/5t7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t7x ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t7x OCA], [https://pdbe.org/5t7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t7x RCSB], [https://www.ebi.ac.uk/pdbsum/5t7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t7x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/EBNA1_EBVG EBNA1_EBVG]] Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival (By similarity).
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[https://www.uniprot.org/uniprot/EBNA1_EBVB9 EBNA1_EBVB9] Plays an essential role in replication and partitioning of viral genomic DNA during latent viral infection. During this phase, the circular double-stranded viral DNA undergoes replication once per cell cycle and is efficiently partitioned to the daughter cells. EBNA1 activates the initiation of viral DNA replication through binding to specific sites in the viral latent origin of replication, oriP. Additionally, it governs the segregation of viral episomes by mediating their attachment to host cell metaphase chromosomes. Also activates the transcription of several viral latency genes. Finally, it can counteract the stabilization of host p53/TP53 by host USP7, thereby decreasing apoptosis and increasing host cell survival.<ref>PMID:15808506</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human herpesvirus 4 strain B95-8]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lieberman, P M]]
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[[Category: Lieberman PM]]
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[[Category: Malecka, K A]]
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[[Category: Malecka KA]]
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[[Category: Messick, T E]]
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[[Category: Messick TE]]
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[[Category: Dimer]]
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[[Category: Dna]]
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[[Category: Dna binding protein-dna complex]]
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Current revision

Crystal structure of HHV-4 EBNA1 DNA binding domain (patient-derived, nasopharyngeal carcinoma) bound to DNA

PDB ID 5t7x

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OCA

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