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5uc7

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==Crystal structure of BioA / 7,8-diaminopelargonic acid aminotransferase / DAPA synthase from Citrobacter rodentium, PLP complex==
==Crystal structure of BioA / 7,8-diaminopelargonic acid aminotransferase / DAPA synthase from Citrobacter rodentium, PLP complex==
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<StructureSection load='5uc7' size='340' side='right' caption='[[5uc7]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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<StructureSection load='5uc7' size='340' side='right'caption='[[5uc7]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uc7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Environmental_samples Environmental samples]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UC7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uc7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Environmental_samples Environmental samples]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UC7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.835&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bioA, ROD_07751 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=97825 environmental samples])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uc7 OCA], [https://pdbe.org/5uc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uc7 RCSB], [https://www.ebi.ac.uk/pdbsum/5uc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uc7 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine--8-amino-7-oxononanoate_transaminase Adenosylmethionine--8-amino-7-oxononanoate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.62 2.6.1.62] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uc7 OCA], [http://pdbe.org/5uc7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uc7 RCSB], [http://www.ebi.ac.uk/pdbsum/5uc7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uc7 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/D2TPI3_CITRI D2TPI3_CITRI]] Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.[HAMAP-Rule:MF_00834]
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[https://www.uniprot.org/uniprot/D2TPI3_CITRI D2TPI3_CITRI] Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor.[HAMAP-Rule:MF_00834]
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==See Also==
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*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
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*[[7%2C8-diaminopelargonic acid synthase 3D structures|7%2C8-diaminopelargonic acid synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]]
 
[[Category: Environmental samples]]
[[Category: Environmental samples]]
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[[Category: Anderson, W F]]
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[[Category: Large Structures]]
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[[Category: Structural genomic]]
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[[Category: Anderson WF]]
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[[Category: Evdokimova, E]]
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[[Category: Di Leo R]]
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[[Category: Leo, R Di]]
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[[Category: Evdokimova E]]
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[[Category: Savchenko, A]]
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[[Category: Savchenko A]]
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[[Category: Stogios, P J]]
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[[Category: Stogios PJ]]
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[[Category: 8-diaminopelargonic acid]]
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[[Category: Aminotransferase]]
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[[Category: Biotin biosynthesis]]
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[[Category: Csgid]]
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[[Category: Dapa]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Plp-dependent fold type i sub class ii aminotransferase]]
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[[Category: Pyridoxal-5'-phosphate]]
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[[Category: Transferase]]
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Current revision

Crystal structure of BioA / 7,8-diaminopelargonic acid aminotransferase / DAPA synthase from Citrobacter rodentium, PLP complex

PDB ID 5uc7

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