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5uio

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==structure of DHFR with bound DAP, p-ABG and NADP==
==structure of DHFR with bound DAP, p-ABG and NADP==
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<StructureSection load='5uio' size='340' side='right' caption='[[5uio]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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<StructureSection load='5uio' size='340' side='right'caption='[[5uio]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uio]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UIO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uio]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UIO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8DM:N-(4-aminobenzene-1-carbonyl)-L-glutamic+acid'>8DM</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=LG3:PYRIMIDINE-2,4-DIAMINE'>LG3</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.929&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uih|5uih]], [[5uii|5uii]], [[5uip|5uip]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8DM:N-(4-aminobenzene-1-carbonyl)-L-glutamic+acid'>8DM</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=LG3:PYRIMIDINE-2,4-DIAMINE'>LG3</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uio OCA], [https://pdbe.org/5uio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uio RCSB], [https://www.ebi.ac.uk/pdbsum/5uio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uio ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uio OCA], [http://pdbe.org/5uio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uio RCSB], [http://www.ebi.ac.uk/pdbsum/5uio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uio ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5uio" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5uio" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dihydrofolate reductase]]
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[[Category: Escherichia coli]]
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[[Category: London, R E]]
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[[Category: Large Structures]]
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[[Category: Pedersen, L C]]
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[[Category: London RE]]
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[[Category: Diaminopyridine]]
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[[Category: Pedersen LC]]
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[[Category: Dhfr]]
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[[Category: Nadp]]
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[[Category: Oxidoreductase]]
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Current revision

structure of DHFR with bound DAP, p-ABG and NADP

PDB ID 5uio

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