This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5uos

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:31, 4 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12==
==Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12==
-
<StructureSection load='5uos' size='340' side='right' caption='[[5uos]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
+
<StructureSection load='5uos' size='340' side='right'caption='[[5uos]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5uos]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UOS FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5uos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UOS FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=171:2-PHENYLAMINO-ETHANESULFONIC+ACID'>171</scene>, <scene name='pdbligand=8FS:1-ethynyl-2,4-difluorobenzene'>8FS</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uos OCA], [http://pdbe.org/5uos PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uos RCSB], [http://www.ebi.ac.uk/pdbsum/5uos PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uos ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=171:2-PHENYLAMINO-ETHANESULFONIC+ACID'>171</scene>, <scene name='pdbligand=8FS:1-ethynyl-2,4-difluorobenzene'>8FS</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uos OCA], [https://pdbe.org/5uos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uos RCSB], [https://www.ebi.ac.uk/pdbsum/5uos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uos ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/MMAC_HUMAN MMAC_HUMAN]] Methylmalonic acidemia with homocystinuria, type cblC. The disease is caused by mutations affecting the gene represented in this entry.
+
[https://www.uniprot.org/uniprot/MMAC_HUMAN MMAC_HUMAN] Methylmalonic acidemia with homocystinuria, type cblC. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MMAC_HUMAN MMAC_HUMAN]] May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
+
[https://www.uniprot.org/uniprot/MMAC_HUMAN MMAC_HUMAN] May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Banerjee, R]]
+
[[Category: Homo sapiens]]
-
[[Category: Karasik, A]]
+
[[Category: Large Structures]]
-
[[Category: Koutmos, M]]
+
[[Category: Banerjee R]]
-
[[Category: Krautler, B]]
+
[[Category: Karasik A]]
-
[[Category: Ruetz, M]]
+
[[Category: Koutmos M]]
-
[[Category: Shanmuganathan, A]]
+
[[Category: Krautler B]]
-
[[Category: B12 binding]]
+
[[Category: Ruetz M]]
-
[[Category: B12 processing]]
+
[[Category: Shanmuganathan A]]
-
[[Category: B12 trafficking]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Vitamin b12]]
+

Current revision

Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12

PDB ID 5uos

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5uos"
Personal tools