This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5uum

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:34, 4 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Human Mcl-1 in complex with a Bfl-1-specific selected peptide==
==Human Mcl-1 in complex with a Bfl-1-specific selected peptide==
-
<StructureSection load='5uum' size='340' side='right' caption='[[5uum]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
+
<StructureSection load='5uum' size='340' side='right'caption='[[5uum]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5uum]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UUM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5uum]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UUM FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.346&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uuk|5uuk]], [[5uul|5uul]], [[5uup|5uup]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uum OCA], [https://pdbe.org/5uum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uum RCSB], [https://www.ebi.ac.uk/pdbsum/5uum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uum ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uum OCA], [http://pdbe.org/5uum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uum RCSB], [http://www.ebi.ac.uk/pdbsum/5uum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uum ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
+
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 19:
</div>
</div>
<div class="pdbe-citations 5uum" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5uum" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Grant, R A]]
+
[[Category: Homo sapiens]]
-
[[Category: Jenson, J M]]
+
[[Category: Large Structures]]
-
[[Category: Keating, A E]]
+
[[Category: Synthetic construct]]
-
[[Category: Apoptosis]]
+
[[Category: Grant RA]]
-
[[Category: Apoptosis regulatory protein]]
+
[[Category: Jenson JM]]
-
[[Category: Bcl2 related protein a1]]
+
[[Category: Keating AE]]
-
[[Category: Bcl2a1]]
+
-
[[Category: Peptide inhibitor]]
+
-
[[Category: Peptide library]]
+
-
[[Category: Protein binding]]
+
-
[[Category: Protein structure]]
+
-
[[Category: Proto-oncogene]]
+
-
[[Category: Specificity]]
+

Current revision

Human Mcl-1 in complex with a Bfl-1-specific selected peptide

PDB ID 5uum

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5uum"
Personal tools