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5vph

From Proteopedia

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Current revision (13:54, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5vph' size='340' side='right'caption='[[5vph]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5vph' size='340' side='right'caption='[[5vph]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vph]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3rvx 3rvx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VPH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vph]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3rvx 3rvx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VPH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rvt|3rvt]], [[3rvu|3rvu]], [[3rvv|3rvv]], [[3rvw|3rvw]], [[5vpg|5vpg]], [[5vpk|5vpk]], [[5vpl|5vpl]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vph OCA], [https://pdbe.org/5vph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vph RCSB], [https://www.ebi.ac.uk/pdbsum/5vph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vph ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vph OCA], [https://pdbe.org/5vph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vph RCSB], [https://www.ebi.ac.uk/pdbsum/5vph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vph ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PEPT1_DERPT PEPT1_DERPT] Thiol protease, with a preference for substrates with a large hydrophobic side chain in the P2 position, or with basic residues.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Dermatophagoides pteronyssinus]]
[[Category: Dermatophagoides pteronyssinus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Chapman, M D]]
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[[Category: Chapman MD]]
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[[Category: Chruszcz, M]]
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[[Category: Chruszcz M]]
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[[Category: Minor, W]]
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[[Category: Minor W]]
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[[Category: Pomes, A]]
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[[Category: Pomes A]]
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[[Category: Vailes, L D]]
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[[Category: Vailes LD]]
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[[Category: Allergen-antibody complex]]
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[[Category: Der p 1]]
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[[Category: Hydrolase-immune system complex]]
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Current revision

CRYSTAL STRUCTURE OF DER P 1 COMPLEXED WITH FAB 4C1

PDB ID 5vph

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