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5vqf

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==Crystal Structure of pro-TGF-beta 1==
==Crystal Structure of pro-TGF-beta 1==
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<StructureSection load='5vqf' size='340' side='right' caption='[[5vqf]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='5vqf' size='340' side='right'caption='[[5vqf]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vqf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VQF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vqf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VQF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rjr|3rjr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TGFB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vqf OCA], [https://pdbe.org/5vqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vqf RCSB], [https://www.ebi.ac.uk/pdbsum/5vqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vqf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vqf OCA], [http://pdbe.org/5vqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vqf RCSB], [http://www.ebi.ac.uk/pdbsum/5vqf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vqf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TGFB1_PIG TGFB1_PIG]] Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity).
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[https://www.uniprot.org/uniprot/TGFB1_PIG TGFB1_PIG] Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pig]]
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[[Category: Large Structures]]
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[[Category: Dong, X]]
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[[Category: Sus scrofa]]
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[[Category: Lu, C]]
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[[Category: Dong X]]
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[[Category: Springer, T A]]
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[[Category: Lu C]]
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[[Category: Xu, S]]
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[[Category: Springer TA]]
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[[Category: Zhao, B]]
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[[Category: Xu S]]
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[[Category: Homodimer]]
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[[Category: Zhao B]]
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[[Category: Latency]]
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[[Category: Pro-complex]]
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[[Category: Protein binding]]
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Current revision

Crystal Structure of pro-TGF-beta 1

PDB ID 5vqf

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