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5wan

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(New page: ==Crystal Structure of a flavoenzyme RutA in the pyrimidine catabolic pathway== <StructureSection load='5wan' size='340' side='right' caption='5wan, resolution 1.80&Ari...)
Current revision (14:09, 4 October 2023) (edit) (undo)
 
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==Crystal Structure of a flavoenzyme RutA in the pyrimidine catabolic pathway==
==Crystal Structure of a flavoenzyme RutA in the pyrimidine catabolic pathway==
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<StructureSection load='5wan' size='340' side='right' caption='[[5wan]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5wan' size='340' side='right'caption='[[5wan]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wan]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WAN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wan]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WAN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.798&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Oxidoreductase Oxidoreductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.46 1.14.99.46] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wan OCA], [http://pdbe.org/5wan PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wan RCSB], [http://www.ebi.ac.uk/pdbsum/5wan PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wan ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wan OCA], [https://pdbe.org/5wan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wan RCSB], [https://www.ebi.ac.uk/pdbsum/5wan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wan ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A1R1KFF4_ECOLX A0A1R1KFF4_ECOLX]] Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate.[HAMAP-Rule:MF_01699][SAAS:SAAS00636259]
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[https://www.uniprot.org/uniprot/RUTA_ECOLI RUTA_ECOLI] Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. Requires the flavin reductase RutF to regenerate FMN in vivo. RutF can be substituted by Fre in vitro.<ref>PMID:16540542</ref> <ref>PMID:20400551</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wan" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wan" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Oxidoreductase]]
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[[Category: Escherichia coli]]
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[[Category: Abdelwahed, S]]
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[[Category: Large Structures]]
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[[Category: Begley, T P]]
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[[Category: Abdelwahed S]]
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[[Category: Ealick, S E]]
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[[Category: Begley TP]]
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[[Category: Mukherjee, T]]
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[[Category: Ealick SE]]
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[[Category: Zhang, Y]]
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[[Category: Mukherjee T]]
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[[Category: Flavoenzyme]]
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[[Category: Zhang Y]]

Current revision

Crystal Structure of a flavoenzyme RutA in the pyrimidine catabolic pathway

PDB ID 5wan

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