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5wmt

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Current revision (14:17, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5wmt' size='340' side='right'caption='[[5wmt]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
<StructureSection load='5wmt' size='340' side='right'caption='[[5wmt]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wmt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Canlf Canlf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wmt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WMT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9QY:methyl+2-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate'>9QY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.748&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vyy|5vyy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9QY:methyl+2-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate'>9QY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90B1, GRP94, TRA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmt OCA], [https://pdbe.org/5wmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wmt RCSB], [https://www.ebi.ac.uk/pdbsum/5wmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmt OCA], [http://pdbe.org/5wmt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmt RCSB], [http://www.ebi.ac.uk/pdbsum/5wmt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmt ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF]] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
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[https://www.uniprot.org/uniprot/ENPL_CANLF ENPL_CANLF] Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wmt" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wmt" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Canlf]]
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[[Category: Canis lupus familiaris]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gewirth, D T]]
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[[Category: Gewirth DT]]
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[[Category: Que, N S]]
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[[Category: Que NS]]
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[[Category: Chaperone]]
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[[Category: Chaperone-inhibitor complex]]
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[[Category: Complex]]
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[[Category: Inhibitor]]
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Current revision

Structure of GRP94 N-terminal Domain bound to resorcinylic inhibitor BnIm.

PDB ID 5wmt

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OCA

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