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5wna

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==Structure of antibody 3D3 bound to the central conserved region of RSV G==
==Structure of antibody 3D3 bound to the central conserved region of RSV G==
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<StructureSection load='5wna' size='340' side='right' caption='[[5wna]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='5wna' size='340' side='right'caption='[[5wna]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wna]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrsva Hrsva] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WNA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wna]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A2 Human respiratory syncytial virus A2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WNA FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wna OCA], [http://pdbe.org/5wna PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wna RCSB], [http://www.ebi.ac.uk/pdbsum/5wna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wna ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wna OCA], [https://pdbe.org/5wna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wna RCSB], [https://www.ebi.ac.uk/pdbsum/5wna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wna ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA]] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.
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[https://www.uniprot.org/uniprot/GLYC_HRSVA GLYC_HRSVA] Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wna" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wna" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hrsva]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Human respiratory syncytial virus A2]]
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[[Category: DuBois, R M]]
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[[Category: Large Structures]]
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[[Category: Fedechkin, S O]]
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[[Category: DuBois RM]]
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[[Category: George, N L]]
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[[Category: Fedechkin SO]]
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[[Category: Kauvar, L M]]
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[[Category: George NL]]
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[[Category: Wolff, J T]]
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[[Category: Kauvar LM]]
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[[Category: Antibody]]
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[[Category: Wolff JT]]
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[[Category: G glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: Rsv]]
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[[Category: Viral attachment protein]]
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[[Category: Viral protein]]
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[[Category: Viral protein-immune system complex]]
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Current revision

Structure of antibody 3D3 bound to the central conserved region of RSV G

PDB ID 5wna

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