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6b60

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Current revision (14:33, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6b60' size='340' side='right'caption='[[6b60]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='6b60' size='340' side='right'caption='[[6b60]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6b60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfu Arcfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B60 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6b60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus_DSM_4304 Archaeoglobus fulgidus DSM 4304]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B60 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">suhB, AF_2372 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224325 ARCFU])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b60 OCA], [http://pdbe.org/6b60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b60 RCSB], [http://www.ebi.ac.uk/pdbsum/6b60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b60 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b60 OCA], [https://pdbe.org/6b60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b60 RCSB], [https://www.ebi.ac.uk/pdbsum/6b60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b60 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BSUHB_ARCFU BSUHB_ARCFU]] Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P), 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate and fructose-6-phosphate. May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate.<ref>PMID:10747806</ref> <ref>PMID:11062561</ref> <ref>PMID:11940584</ref>
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[https://www.uniprot.org/uniprot/BSUHB_ARCFU BSUHB_ARCFU] Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P), 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate and fructose-6-phosphate. May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate.<ref>PMID:10747806</ref> <ref>PMID:11062561</ref> <ref>PMID:11940584</ref>
==See Also==
==See Also==
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*[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]]
*[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]]
*[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arcfu]]
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[[Category: Archaeoglobus fulgidus DSM 4304]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Goldstein, R I]]
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[[Category: Goldstein RI]]
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[[Category: Roberts, M F]]
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[[Category: Roberts MF]]
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[[Category: Hydrolase]]
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[[Category: Osmolyte binding protein inositol mono phosphatase]]
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Current revision

IMPase (AF2372) with 25 mM Glutamate

PDB ID 6b60

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