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6ble

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==Crystal Structure of the Human CAMKK2B in complex with CP673451==
==Crystal Structure of the Human CAMKK2B in complex with CP673451==
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<StructureSection load='6ble' size='340' side='right' caption='[[6ble]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='6ble' size='340' side='right'caption='[[6ble]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ble]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BLE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ble]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BLE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34U:1-{2-[5-(2-METHOXYETHOXY)-1H-BENZIMIDAZOL-1-YL]QUINOLIN-8-YL}PIPERIDIN-4-AMINE'>34U</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAMKK2, CAMKKB, KIAA0787 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34U:1-{2-[5-(2-METHOXYETHOXY)-1H-BENZIMIDAZOL-1-YL]QUINOLIN-8-YL}PIPERIDIN-4-AMINE'>34U</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ble FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ble OCA], [https://pdbe.org/6ble PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ble RCSB], [https://www.ebi.ac.uk/pdbsum/6ble PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ble ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ble FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ble OCA], [http://pdbe.org/6ble PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ble RCSB], [http://www.ebi.ac.uk/pdbsum/6ble PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ble ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>
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[https://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>
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==See Also==
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*[[Calcium/calmodulin-dependent protein kinase kinase|Calcium/calmodulin-dependent protein kinase kinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Arruda, P]]
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[[Category: Arruda P]]
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[[Category: Counago, R M]]
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[[Category: Counago RM]]
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[[Category: Drewry, D]]
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[[Category: Drewry D]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Elkins, J M]]
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[[Category: Elkins JM]]
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[[Category: Massirer, K B]]
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[[Category: Massirer KB]]
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[[Category: Ramos, P Z]]
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[[Category: Ramos PZ]]
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[[Category: Reis, C V.dos]]
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[[Category: De Souza GP]]
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[[Category: Structural genomic]]
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[[Category: Dos Reis CV]]
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[[Category: Souza, G P.de]]
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[[Category: Protein kinase domain]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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[[Category: Transferase inhibitor complex]]
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Current revision

Crystal Structure of the Human CAMKK2B in complex with CP673451

PDB ID 6ble

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