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6bru
From Proteopedia
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==Crystal Structure of the Human vaccinia-related kinase bound to a (S)-2-phenylaminopteridinone inhibitor== | ==Crystal Structure of the Human vaccinia-related kinase bound to a (S)-2-phenylaminopteridinone inhibitor== | ||
| - | <StructureSection load='6bru' size='340' side='right' caption='[[6bru]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='6bru' size='340' side='right'caption='[[6bru]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6bru]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BRU OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6bru]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BRU FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E5M:(7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one'>E5M</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E5M:(7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one'>E5M</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bru OCA], [https://pdbe.org/6bru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bru RCSB], [https://www.ebi.ac.uk/pdbsum/6bru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bru ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.<ref>PMID:10951572</ref> <ref>PMID:14645249</ref> <ref>PMID:15105425</ref> <ref>PMID:16495336</ref> <ref>PMID:18617507</ref> <ref>PMID:19103756</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Aquino | + | [[Category: Large Structures]] |
| - | [[Category: Arruda | + | [[Category: Aquino B]] |
| - | [[Category: Azevedo | + | [[Category: Arruda P]] |
| - | [[Category: Counago | + | [[Category: Azevedo A]] |
| - | [[Category: Edwards | + | [[Category: Counago RM]] |
| - | [[Category: Elkins | + | [[Category: Edwards AM]] |
| - | [[Category: Ferreira | + | [[Category: Elkins JM]] |
| - | [[Category: Gama | + | [[Category: Ferreira M]] |
| - | [[Category: Guimaraes | + | [[Category: Gama F]] |
| - | [[Category: Mascarello | + | [[Category: Guimaraes C]] |
| - | [[Category: Massirer | + | [[Category: Mascarello A]] |
| - | + | [[Category: Massirer KB]] | |
| - | + | [[Category: De Souza GP]] | |
| - | [[Category: Souza | + | [[Category: Dos Reis CV]] |
| - | [[Category: | + | |
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Current revision
Crystal Structure of the Human vaccinia-related kinase bound to a (S)-2-phenylaminopteridinone inhibitor
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Categories: Homo sapiens | Large Structures | Aquino B | Arruda P | Azevedo A | Counago RM | Edwards AM | Elkins JM | Ferreira M | Gama F | Guimaraes C | Mascarello A | Massirer KB | De Souza GP | Dos Reis CV
