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6c5z

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Current revision (14:56, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6c5z' size='340' side='right'caption='[[6c5z]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
<StructureSection load='6c5z' size='340' side='right'caption='[[6c5z]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6c5z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C5Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6c5z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C5Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6c58|6c58]], [[6c5a|6c5a]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UGDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5z OCA], [https://pdbe.org/6c5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c5z RCSB], [https://www.ebi.ac.uk/pdbsum/6c5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5z ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c5z OCA], [http://pdbe.org/6c5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c5z RCSB], [http://www.ebi.ac.uk/pdbsum/6c5z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c5z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UGDH_HUMAN UGDH_HUMAN]] Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
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[https://www.uniprot.org/uniprot/UGDH_HUMAN UGDH_HUMAN] Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: UDP-glucose 6-dehydrogenase]]
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[[Category: Gross PG]]
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[[Category: Gross, P G]]
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[[Category: Peeples WB]]
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[[Category: Peeples, W B]]
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[[Category: Sidlo AM]]
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[[Category: Sidlo, A M]]
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[[Category: Walsh RM]]
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[[Category: Walsh, R M]]
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[[Category: Wood ZA]]
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[[Category: Wood, Z A]]
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[[Category: Dehydrogenase]]
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[[Category: Hugdh]]
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[[Category: Nadh]]
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[[Category: Oxidoreductase]]
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[[Category: Udp-glucose]]
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Current revision

Human UDP-Glucose Dehydrogenase A225L substitutuion with UDP-glucose and NADH bound

PDB ID 6c5z

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