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6chi

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==Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 amide==
==Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 amide==
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<StructureSection load='6chi' size='340' side='right' caption='[[6chi]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='6chi' size='340' side='right'caption='[[6chi]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6chi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CHI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6chi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CHI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3NX:3-hydroxy-17-(3-pyridyl)-androst-5,16-dien-6-amide'>3NX</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.698&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP17A1, CYP17, S17AH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3NX:3-hydroxy-17-(3-pyridyl)-androst-5,16-dien-6-amide'>3NX</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6chi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6chi OCA], [http://pdbe.org/6chi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6chi RCSB], [http://www.ebi.ac.uk/pdbsum/6chi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6chi ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6chi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6chi OCA], [https://pdbe.org/6chi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6chi RCSB], [https://www.ebi.ac.uk/pdbsum/6chi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6chi ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN]] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref>
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[https://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6chi" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6chi" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Scott, E E]]
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[[Category: Large Structures]]
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[[Category: 17a-hydroxylase]]
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[[Category: Scott EE]]
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[[Category: Cyp17a1]]
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[[Category: Cytochrome p450]]
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[[Category: Cytochrome p450 oxidoreductase]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Heme protein]]
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[[Category: Membrane]]
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[[Category: Microsome]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: P450]]
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[[Category: P450 17a1]]
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[[Category: P450c17]]
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Current revision

Human Cytochrome P450 17A1 in complex with inhibitor: abiraterone C6 amide

PDB ID 6chi

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