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6cxk

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==E. coli DHFR substrate complex with Dihydrofolate==
==E. coli DHFR substrate complex with Dihydrofolate==
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<StructureSection load='6cxk' size='340' side='right' caption='[[6cxk]], [[Resolution|resolution]] 1.11&Aring;' scene=''>
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<StructureSection load='6cxk' size='340' side='right'caption='[[6cxk]], [[Resolution|resolution]] 1.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6cxk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CXK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6cxk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_CFT073 Escherichia coli CFT073]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CXK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.108&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6cw7|6cw7]], [[6cqa|6cqa]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DHF:DIHYDROFOLIC+ACID'>DHF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxk OCA], [https://pdbe.org/6cxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cxk RCSB], [https://www.ebi.ac.uk/pdbsum/6cxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cxk OCA], [http://pdbe.org/6cxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cxk RCSB], [http://www.ebi.ac.uk/pdbsum/6cxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cxk ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DYR_ECOL6 DYR_ECOL6]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).
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[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6cxk" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6cxk" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dihydrofolate reductase]]
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[[Category: Escherichia coli CFT073]]
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[[Category: Benach, J]]
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[[Category: Large Structures]]
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[[Category: Cao, H]]
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[[Category: Benach J]]
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[[Category: Frommelt, A]]
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[[Category: Cao H]]
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[[Category: Koss, J]]
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[[Category: Frommelt A]]
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[[Category: Morisco, L]]
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[[Category: Koss J]]
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[[Category: Rodrigues, J]]
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[[Category: Morisco L]]
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[[Category: Shakhnovich, E]]
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[[Category: Rodrigues J]]
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[[Category: Skolnick, J]]
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[[Category: Shakhnovich E]]
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[[Category: Complex]]
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[[Category: Skolnick J]]
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[[Category: Dhfr]]
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[[Category: Dihydrofolate]]
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[[Category: Oxidoreductase]]
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Current revision

E. coli DHFR substrate complex with Dihydrofolate

PDB ID 6cxk

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