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3asx

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==Human Squalene synthase in complex with 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid==
==Human Squalene synthase in complex with 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid==
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<StructureSection load='3asx' size='340' side='right' caption='[[3asx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3asx' size='340' side='right'caption='[[3asx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3asx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ASX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ASX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3asx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ASX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ASX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D99:(3R)-1-{4-[{4-CHLORO-2-[(S)-(2-CHLOROPHENYL)(HYDROXY)METHYL]PHENYL}(2,2-DIMETHYLPROPYL)AMINO]-4-OXOBUTANOYL}PIPERIDINE-3-CARBOXYLIC+ACID'>D99</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q2z|3q2z]], [[3q30|3q30]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D99:(3R)-1-{4-[{4-CHLORO-2-[(S)-(2-CHLOROPHENYL)(HYDROXY)METHYL]PHENYL}(2,2-DIMETHYLPROPYL)AMINO]-4-OXOBUTANOYL}PIPERIDINE-3-CARBOXYLIC+ACID'>D99</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDFT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3asx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3asx OCA], [https://pdbe.org/3asx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3asx RCSB], [https://www.ebi.ac.uk/pdbsum/3asx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3asx ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3asx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3asx OCA], [http://pdbe.org/3asx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3asx RCSB], [http://www.ebi.ac.uk/pdbsum/3asx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3asx ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FDFT_HUMAN FDFT_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Squalene synthase]]
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[[Category: Large Structures]]
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[[Category: Higashihashi, N]]
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[[Category: Higashihashi N]]
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[[Category: Ichikawa, M]]
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[[Category: Ichikawa M]]
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[[Category: Itoh, M]]
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[[Category: Itoh M]]
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[[Category: Katakura, S]]
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[[Category: Katakura S]]
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[[Category: Shimizu, H]]
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[[Category: Shimizu H]]
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[[Category: Sugita, K]]
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[[Category: Sugita K]]
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[[Category: Suzuki, M]]
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[[Category: Suzuki M]]
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[[Category: Usui, H]]
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[[Category: Usui H]]
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[[Category: Yamazaki, K]]
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[[Category: Yamazaki K]]
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[[Category: Yokomizo, A]]
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[[Category: Yokomizo A]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Lipid synthesis]]
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[[Category: Multifunctional enzyme]]
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[[Category: Oxidoreductase]]
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[[Category: Steroid biosynthesis]]
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[[Category: Sterol biosynthesis]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Human Squalene synthase in complex with 1-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid

PDB ID 3asx

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OCA

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