3av3

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[[Image:3av3.jpg|left|200px]]
 
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==Crystal structure of glycinamide ribonucleotide transformylase 1 from Geobacillus kaustophilus==
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The line below this paragraph, containing "STRUCTURE_3av3", creates the "Structure Box" on the page.
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<StructureSection load='3av3' size='340' side='right'caption='[[3av3]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3av3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_kaustophilus_HTA426 Geobacillus kaustophilus HTA426]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AV3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3av3| PDB=3av3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3av3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3av3 OCA], [https://pdbe.org/3av3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3av3 RCSB], [https://www.ebi.ac.uk/pdbsum/3av3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3av3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5L3C9_GEOKA Q5L3C9_GEOKA]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structures of glycinamide ribonucleotide transformylases (PurNs) from Aquifex aeolicus (Aa), Geobacillus kaustophilus (Gk) and Symbiobacterium toebii (St), and of formyltetrahydrofolate hydrolase (PurU) from Thermus thermophilus (Tt) were determined. The monomer structures of the determined PurN and PurU were very similar to the known structure of PurN, but oligomeric states were different; AaPurN and StPurN formed dimers, GkPurN formed monomer and PurU formed tetramer in the crystals. PurU had a regulatory ACT domain in its N-terminal side. So far several structures of PurUs have been determined, yet, the mechanisms of the catalysis and the regulation of PurU have not been elucidated. We, therefore, modelled ligand-bound structures of PurN and PurU, and performed molecular dynamics simulations to elucidate the reaction mechanisms. The evolutionary relationship of the two enzymes is discussed based on the comparisons of the structures and the catalytic mechanisms.
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===Crystal structure of glycinamide ribonucleotide transformylase 1 from Geobacillus kaustophilus===
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Structures and reaction mechanisms of the two related enzymes, PurN and PurU.,Sampei G, Kanagawa M, Baba S, Shimasaki T, Taka H, Mitsui S, Fujiwara S, Yanagida Y, Kusano M, Suzuki S, Terao K, Kawai H, Fukai Y, Nakagawa N, Ebihara A, Kuramitsu S, Yokoyama S, Kawai G J Biochem. 2013 Dec;154(6):569-79. doi: 10.1093/jb/mvt090. Epub 2013 Oct 9. PMID:24108189<ref>PMID:24108189</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3av3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_kaustophilus Geobacillus kaustophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AV3 OCA].
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<div class="pdbe-citations 3av3" style="background-color:#fffaf0;"></div>
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[[Category: Geobacillus kaustophilus]]
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== References ==
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[[Category: Phosphoribosylglycinamide formyltransferase]]
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<references/>
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[[Category: Baba, S.]]
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__TOC__
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[[Category: Ebihara, A.]]
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</StructureSection>
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[[Category: Kanagawa, M.]]
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[[Category: Geobacillus kaustophilus HTA426]]
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[[Category: Kawai, G.]]
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[[Category: Large Structures]]
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[[Category: Kuramitsu, S.]]
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[[Category: Baba S]]
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[[Category: Nakagawa, N.]]
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[[Category: Ebihara A]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Kanagawa M]]
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[[Category: Sampei, G.]]
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[[Category: Kawai G]]
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[[Category: Yokoyama, S.]]
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[[Category: Kuramitsu S]]
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[[Category: Folate binding]]
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[[Category: Nakagawa N]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Sampei G]]
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[[Category: Rossmann fold]]
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[[Category: Yokoyama S]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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[[Category: Transformylase]]
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Current revision

Crystal structure of glycinamide ribonucleotide transformylase 1 from Geobacillus kaustophilus

PDB ID 3av3

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