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3ave

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{{STRUCTURE_3ave| PDB=3ave | SCENE= }}
 
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===Crystal Structure of the Fucosylated Fc Fragment from Human Immunoglobulin G1===
 
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{{ABSTRACT_PUBMED_17368483}}
 
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==Disease==
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==Crystal Structure of the Fucosylated Fc Fragment from Human Immunoglobulin G1==
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[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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<StructureSection load='3ave' size='340' side='right'caption='[[3ave]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3ave]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2dtq 2dtq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AVE FirstGlance]. <br>
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[[3ave]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2dtq 2dtq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVE OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ave FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ave OCA], [https://pdbe.org/3ave PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ave RCSB], [https://www.ebi.ac.uk/pdbsum/3ave PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ave ProSAT]</span></td></tr>
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<ref group="xtra">PMID:017368483</ref><references group="xtra"/><references/>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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== Function ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kato, K.]]
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[[Category: Large Structures]]
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[[Category: Matsumiya, S.]]
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[[Category: Kato K]]
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[[Category: Nagano, M.]]
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[[Category: Matsumiya S]]
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[[Category: Otaki, S.]]
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[[Category: Nagano M]]
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[[Category: Saito, J.]]
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[[Category: Otaki S]]
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[[Category: Sasakawa, H.]]
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[[Category: Saito J]]
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[[Category: Satoh, M.]]
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[[Category: Sasakawa H]]
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[[Category: Shitara, K.]]
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[[Category: Satoh M]]
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[[Category: Yamaguchi, Y.]]
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[[Category: Shitara K]]
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[[Category: Igg1]]
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[[Category: Yamaguchi Y]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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[[Category: Immunoglobulin-like beta-sandwich]]
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Current revision

Crystal Structure of the Fucosylated Fc Fragment from Human Immunoglobulin G1

PDB ID 3ave

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