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3avu

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[[Image:3avu.jpg|left|200px]]
 
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==Structure of viral RNA polymerase complex 2==
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The line below this paragraph, containing "STRUCTURE_3avu", creates the "Structure Box" on the page.
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<StructureSection load='3avu' size='340' side='right'caption='[[3avu]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3avu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7], [https://en.wikipedia.org/wiki/Escherichia_virus_Qbeta Escherichia virus Qbeta] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AVU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.907&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3avu| PDB=3avu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3avu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3avu OCA], [https://pdbe.org/3avu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3avu RCSB], [https://www.ebi.ac.uk/pdbsum/3avu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3avu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/EFTU_ECO57 EFTU_ECO57] [https://www.uniprot.org/uniprot/RDRP_BPQBE RDRP_BPQBE] This enzyme is part of the viral RNA-dependent RNA polymerase complex.[https://www.uniprot.org/uniprot/EFTS_ECO57 EFTS_ECO57] Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Core Qbeta replicase comprises the Qbeta virus-encoded RNA-dependent RNA polymerase (beta-subunit) and the host Escherichia coli translational elongation factors EF-Tu and EF-Ts. The functions of the host proteins in the viral replicase are not clear. Structural analyses of RNA polymerization by core Qbeta replicase reveal that at the initiation stage, the 3'-adenine of the template RNA provides a stable platform for de novo initiation. EF-Tu in Qbeta replicase forms a template exit channel with the beta-subunit. At the elongation stages, the C-terminal region of the beta-subunit, assisted by EF-Tu, splits the temporarily double-stranded RNA between the template and nascent RNAs before translocation of the single-stranded template RNA into the exit channel. Therefore, EF-Tu in Qbeta replicase modulates RNA elongation processes in a distinct manner from its established function in protein synthesis.
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===Structure of viral RNA polymerase complex 2===
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Molecular basis for RNA polymerization by Qbeta replicase.,Takeshita D, Tomita K Nat Struct Mol Biol. 2012 Jan 15;19(2):229-37. doi: 10.1038/nsmb.2204. PMID:22245970<ref>PMID:22245970</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3avu" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[3avu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7,_escherichia_coli_o157:h7,_synthetic,_enterobacteria_phage_qbeta Escherichia coli o157:h7, escherichia coli o157:h7, synthetic, enterobacteria phage qbeta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AVU OCA].
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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[[Category: Escherichia coli o157:h7, escherichia coli o157:h7, synthetic, enterobacteria phage qbeta]]
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== References ==
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[[Category: Takeshita, D.]]
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<references/>
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[[Category: Tomita, K.]]
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__TOC__
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[[Category: Rna polymerase]]
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</StructureSection>
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[[Category: Transferase-rna complex]]
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[[Category: Escherichia coli O157:H7]]
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[[Category: Translation]]
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[[Category: Escherichia virus Qbeta]]
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Takeshita D]]
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[[Category: Tomita K]]

Current revision

Structure of viral RNA polymerase complex 2

PDB ID 3avu

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