This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5l8a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:10, 4 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.==
==Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.==
-
<StructureSection load='5l8a' size='340' side='right' caption='[[5l8a]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
+
<StructureSection load='5l8a' size='340' side='right'caption='[[5l8a]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5l8a]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L8A FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5l8a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L8A FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6RB:1-(2-HYDROXYETHYL)-5-[(4-METHOXYNAPHTHALEN-1-YL)METHYL]-~{N}-(PHENYLMETHYL)-6,7-DIHYDRO-4~{H}-PYRAZOLO[4,3-C]PYRIDINE-3-CARBOXAMIDE'>6RB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w84|2w84]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6RB:1-(2-HYDROXYETHYL)-5-[(4-METHOXYNAPHTHALEN-1-YL)METHYL]-~{N}-(PHENYLMETHYL)-6,7-DIHYDRO-4~{H}-PYRAZOLO[4,3-C]PYRIDINE-3-CARBOXAMIDE'>6RB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l8a OCA], [http://pdbe.org/5l8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l8a RCSB], [http://www.ebi.ac.uk/pdbsum/5l8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l8a ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l8a OCA], [https://pdbe.org/5l8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l8a RCSB], [https://www.ebi.ac.uk/pdbsum/5l8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l8a ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q8IEW2_TRYBB Q8IEW2_TRYBB]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Dawidowski, M]]
+
[[Category: Large Structures]]
-
[[Category: Emmanouilidis, L]]
+
[[Category: Trypanosoma brucei brucei]]
-
[[Category: Popowicz, G M]]
+
[[Category: Dawidowski M]]
-
[[Category: Sattler, M]]
+
[[Category: Emmanouilidis L]]
-
[[Category: Glycosome]]
+
[[Category: Popowicz GM]]
-
[[Category: Inhibitor]]
+
[[Category: Sattler M]]
-
[[Category: Protein-protein interaction inhibitor]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Structure-based drug discovery]]
+
-
[[Category: Trypanosomiasis]]
+

Current revision

Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.

PDB ID 5l8a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5l8a"
Personal tools