Pyruvate kinase 3D structures

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(New page: ==3D structures of pyruvate kinase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Pyruvate kinase **3bjf, ...)
Current revision (08:26, 5 October 2023) (edit) (undo)
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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*Pyruvate kinase muscle
 +
 +
**[[3bjf]], [[3bjt]], [[1t5a]], [[1zjh]] - hPyK M2 muscle - human<br />
 +
**[[3g2g]], [[6b6u]], [[4qg6]], [[4qg8]], [[4qg9]], [[4qgc]], [[4yj5]], [[4wj8]] - hPyK M2 muscle (mutant) <br />
 +
**[[3srf]], [[3srh]] – hPyK M1 muscle<br />
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**[[6wp3]], [[6wp4]], [[6wp5]], [[6wp6]] – hPyK M2 muscle (mutant)<br />
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**[[1pkm]], [[1pyk]] – PyK muscle – cat <br />
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**[[1f3w]], [[8f5t]] – rPyK muscle – rabbit<br />
 +
**[[1f3x]], [[7r6y]] - rPyK muscle (mutant) <br />
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 +
*Pyruvate kinase muscle binary complexes
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**[[4b2d]] - hPyK M2 muscle + fructose bisphosphate<br />
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**[[4rpp]] - hPyK M2 muscle (mutant) + fructose bisphosphate<br />
 +
**[[4fxj]] - hPyK M2 muscle + phenylalanine<br />
 +
**[[6gg3]] - hPyK M2 muscle + alanine<br />
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**[[6gg4]] - hPyK M2 muscle + phenylalanine<br />
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**[[6gg5]] - hPyK M2 muscle + tryptophan<br />
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**[[6gg6]] - hPyK M2 muscle + serine<br />
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**[[6nub]] - hPyK M2 muscle (mutant) + serine<br />
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**[[6nu1]] - hPyK M2 muscle + cysteine<br />
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**[[6nu5]] - hPyK M2 muscle (mutant) + cysteine<br />
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**[[6ttf]], [[6tti]], [[6ttq]] - hPyK M2 muscle + inhibitor – Cryo EM<br />
 +
**[[6tth]] - hPyK M2 muscle + threonine – Cryo EM<br />
 +
**[[6v74]], [[6v75]] - hPyK M2 muscle + asparagine <br />
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**[[6v76]] - hPyK M2 muscle + valine <br />
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**[[8g2e]] - hPyK muscle + activator <br />
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**[[8f5u]] - rPyK muscle + pyruvate <br />
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*Pyruvate kinase muscle higher complexes
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**[[3me3]] – hPyK M1/M2 muscle + aniline derivative + fructose bisphosphate <br />
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**[[4g1n]] - hPyK M1/M2 muscle + pyridazine derivative + oxalate<br />
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**[[3h6o]] - hPyK M1/M2 muscle + pyridazine derivative + fructose bisphosphate<br />
 +
**[[3gqy]], [[3gr4]], [[3u2z]] - hPyK M1/M2 muscle + piperazine derivative + fructose bisphosphate<br />
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**[[8hmq]], [[8hmr]], [[8hms]], [[8hmu]] - hPyK muscle (mutant) + Pi + fructose bisphosphate<br />
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**[[5x0i]] - hPyK M2 muscle (mutant) + serine + fructose bisphosphate<br />
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**[[7l21]] - hPyK M2 muscle (mutant) + oxalate + fructose bisphosphate<br />
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**[[6jfb]] - hPyK M2 muscle + serine + phosphate<br />
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**[[5x1v]], [[5x1w]] - hPyK M2 muscle + activator + fructose bisphosphate<br />
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**[[4jpg]] - hPyK M1/M2 muscle + pyrimidine derivative +fructosebisphosphate<br />
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**[[3srd]] - hPyK M1/M2 muscle + oxalate + fructose bisphosphate<br />
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**[[4fxf]] - hPyK M1/M2 muscle + oxalate + ATP + fructose bisphosphate<br />
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**[[3n25]] – rPyK M1/M2 muscle + proline + Mn + pyruvate <br />
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**[[2g50]] - rPyK M1/M2 muscle + alanine + Mn + pyruvate<br />
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**[[8f6m]] - rPyK muscle + Ala + Mn + ADP<br />
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**[[1pkn]] - rPyK muscle + Mn + pyruvate<br />
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**[[1aqf]] – rPyK muscle + Mg + phospholactate<br />
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**[[1a49]], [[1a5u]] - rPyK muscle + ATP + oxalate<br />
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*Pyruvate kinase liver
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**[[7qdn]] - hPyK liver (mutant)<br />
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**[[2vgb]] – hPyK liver<br />)
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**[[6nn5]], [[6nn7]], [[6nn8]], 2vgf, 2vgg, 2vgi – hPyK liver (mutant)<br />
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**[[6nn4]] - hPyK M2 liver (mutant) + fructose bisphosphate<br />
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**[[6ech]], [[6eck]] - PyK liver + fructose bisphosphate - rat<br />
 +
**[[5sc8]], [[5sc9]], [[5sca]], [[5scb]], [[5scc]], [[5scd]], [[5sce]], [[5scf]], [[5scg]], [[5sch]], [[5sci]], [[5scj]], [[5sck]], [[5scl]], [[5sdt]], [[7qzu]] - hPyK liver + anthracene derivative + fructose bisphosphate<br />
 +
**[[7frv]], [[7frw]], [[7frx]], [[7fry]], [[7frz]], [[7fs0]], [[7fs1]], [[7fs2]], [[7fs3]], [[7fs4]], [[7fs5]], [[7fs6]], [[7fs8]], [[7fs9]], [[7fsa]], [[7fsb]], [[7fsc]], [[7fsd]] - hPyK liver + modulator + fructose bisphosphate<br />
 +
**[[4ima]], [[4ip7]] - hPyK liver (mutant) + citrate + adenosine + fructose bisphosphate<br />
 +
*Pyruvate kinase
*Pyruvate kinase
-
**[[3bjf]], [[3bjt]], [[1t5a]], [[1zjh]], [[3srf]], [[3srh]] - hPyK M1/M2 - human<br />
+
**[[6du6]] – PyK - mosquito<br />
-
**[[4wj8]], [[4qg6]], [[4qg8]], [[4qg9]], [[4qgc]], [[3g2g]], [[4yj5]], [[6b6u]] - hPyK M1/M2 (mutant)<br />
+
**[[1pky]], [[4yng]], [[6k0k]] – EcPyK - ''Eschericia coli''<br />
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**[[2vgb]] – hPyK R/L<br />
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**[[1e0t]], [[1e0u]], [[8edq]], [[8edr]], [[8eds]], [[8edt]], [[8eq0]], [[8eq1]], [[8eq3]], [[8eu4]] - EcPyK (mutant) <br />
-
**[[2vgf]], [[2vgg]], [[2vgi]] - hPyK R/L (mutant) <br />
+
-
**[[6nn5]], [[6nn7]], [[6nn8]] – hPyK PKLR (mutant)<br />
+
-
**[[1pkm]], [[1pyk]] – PyK – cat<br />
+
-
**[[1f3w]] – rPyK – rabbit<br />
+
-
**[[1f3x]] - rPyK (mutant) <br />
+
-
**[[1pky]], [[4yng]] – EcPyK - ''Eschericia coli''<br />
+
-
**[[1e0t]], [[1e0u]] - EcPyK (mutant) <br />
+
**[[3t05]], [[3t0t]] – SaPyK – ''Staphylococcus aureus''<br />
**[[3t05]], [[3t0t]] – SaPyK – ''Staphylococcus aureus''<br />
**[[3qtg]] – PyK – ''Pyrobaculum aerophilum''<br />
**[[3qtg]] – PyK – ''Pyrobaculum aerophilum''<br />
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**[[5wrp]] - MtPyK – ''Mycobacterium tuberculosis''<br />
**[[5wrp]] - MtPyK – ''Mycobacterium tuberculosis''<br />
**[[3hqn]], [[3e0w]], [[1pkl]] – LmPyK – ''Leishmania mexicana''<br />
**[[3hqn]], [[3e0w]], [[1pkl]] – LmPyK – ''Leishmania mexicana''<br />
-
**[[3khd]] – PyK – ''Plasmodium falciparum''<br />
+
**[[3khd]], [[7z4m]] – PfPyK – ''Plasmodium falciparum''<br />
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**[[7z4q]], [[7z4r]] - PfPyK (mutant)<br />
**[[3gg8]], [[3eoe]] – PyK – ''Toxoplasma gondii''<br />
**[[3gg8]], [[3eoe]] – PyK – ''Toxoplasma gondii''<br />
-
**[[3ma8]], [[4drs]] – PyK – ''Cryptosporidium parvum''<br />
+
**[[3ma8]], [[4drs]] – CpPyK – ''Cryptosporidium parvum''<br />
**[[2e28]] - PyK (mutant) – ''Geobacillus stearothermophilus''<br />
**[[2e28]] - PyK (mutant) – ''Geobacillus stearothermophilus''<br />
 +
**[[7oo1]] – PaPyK – ''Pseudomonas aeruginosa''<br />
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**[[7ueh]] – PyK – ''Zymomonas mobilis''<br />
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**[[8ias]] - SpPyK – ''Streptococcus pneumoniae''<br />
*Pyruvate kinase binary complex
*Pyruvate kinase binary complex
-
**[[4b2d]] - hPyK M1/M2 + fructose bisphosphate<br />
+
**[[3qv9]] – TcPyK + Ponceau S <br />
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**[[4rpp]] - hPyK M2 (mutant) + fructose bisphosphate<br />
+
-
**[[4fxj]] - hPyK M1/M2 + phenylalanine<br />
+
-
**[[6gg3]] - hPyK M2 + alanine<br />
+
-
**[[6gg4]] - hPyK M2 + phenylalanine<br />
+
-
**[[6gg5]] - hPyK M2 + tryptophan<br />
+
-
**[[6gg6]] - hPyK M2 + serine<br />
+
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**[[6nub]] - hPyK M2 (mutant) + serine<br />
+
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**[[6nu1]] - hPyK M2 + cysteine<br />
+
-
**[[6nu5]] - hPyK M2 (mutant) + cysteine<br />
+
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**[[6ech]], [[6eck]] - PyK PKLR + fructose bisphosphate - rat<br />
+
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**[[5x1v]], [[5x1w]] - hPyK M2 + inhibitor<br />
+
-
**[[4rpp]] - hPyK M2 (mutant) + fructose bisphosphate<br />**[[3qv9]] – TcPyK + Ponceau S <br />
+
**[[3qv6]] – LmPyK + acid blue 80<br />
**[[3qv6]] – LmPyK + acid blue 80<br />
-
**[[3e0v]] – LmPyK + sulfate<br />
+
**[[3e0v]] – LmPyK + sulfate <br />
**[[3hqq]] - LmPyK + fructose bisphosphate<br />
**[[3hqq]] - LmPyK + fructose bisphosphate<br />
**[[3qv8]] – LmPyK + benzothiazole<br />
**[[3qv8]] – LmPyK + benzothiazole<br />
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**[[3t07]] – SaPyK + bis-indole alkaloid<br />
**[[3t07]] – SaPyK + bis-indole alkaloid<br />
**[[4hyw]] – TbPyK + fructose bisphosphate – ''Trypanosoma brucei''<br />
**[[4hyw]] – TbPyK + fructose bisphosphate – ''Trypanosoma brucei''<br />
 +
**[[6su1]], [[6su2]] – PyK + citrate – ''Trypanosoma congolense''<br />
**[[5ws8]] - MtPyK + oxalate<br />
**[[5ws8]] - MtPyK + oxalate<br />
**[[6p0y]] - CpPyK + ADP<br />
**[[6p0y]] - CpPyK + ADP<br />
 +
**[[8iav]] - SpPyK + fructose bisphosphate <br />
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**[[8iat]] - SpPyK + oxalate<br />
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**[[8iaw]] - SpPyK + phosphoenolpyruvate<br />
 +
**[[7z4n]] -PfPyK + pyruvate <br />
-
*Pyruvate kinase higher complex
+
*Pyruvate kinase higher complexes
-
**[[3me3]] – hPyK M1/M2 + aniline derivative + fructose bisphosphate<br />
 
-
**[[4g1n]] - hPyK M1/M2 + pyridazine derivative + oxalate<br />
 
-
**[[3h6o]] - hPyK M1/M2 + pyridazine derivative + fructose bisphosphate<br />
 
-
**[[3gqy]], [[3gr4]], [[3u2z]] - hPyK M1/M2 + piperazine derivative + fructose bisphosphate<br />
 
-
**[[5x0i]] - hPyK M2 (mutant) + serine + fructose bisphosphate<br />
 
-
**[[5x1v]], [[5x1w]] - hPyK M2 + activator + fructose bisphosphate<br />
 
-
**[[4jpg]] - hPyK M1/M2 + pyrimidine derivative + fructose bisphosphate<br />
 
-
**[[3srd]] - hPyK M1/M2 + oxalate + fructose bisphosphate<br />
 
-
**[[4fxf]] - hPyK M1/M2 + oxalate + ATP + fructose bisphosphate<br />
 
-
**[[4ima]], [[4ip7]] - hPyK L (mutant) + citrate + adenosine + fructose bisphosphate<br />
 
-
**[[3n25]] – rPyK M1/M2 + proline + Mn + pyruvate<br />
 
-
**[[2g50]] - rPyK M1/M2 + alanine + Mn + pyruvate<br />
 
-
**[[1pkn]] - rPyK + Mn + pyruvate<br />
 
-
**[[1aqf]] – rPyK + Mg + phospholactate<br />
 
-
**[[1a49]], [[1a5u]] - rPyK + ATP + oxalate<br />
 
**[[1a3w]] – yPyK + Mn + phosphoglycolic acid + fructose bisphosphate – yeast<br />
**[[1a3w]] – yPyK + Mn + phosphoglycolic acid + fructose bisphosphate – yeast<br />
**[[1a3x]] - yPyK + Mn + phosphoglycolic acid<br />
**[[1a3x]] - yPyK + Mn + phosphoglycolic acid<br />
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**[[3qv7]] – LmPyK + acid blue 25 + Ponceau S<br />
**[[3qv7]] – LmPyK + acid blue 25 + Ponceau S<br />
**[[3srk]] – LmPyK + saccharine + inhibitor<br />
**[[3srk]] – LmPyK + saccharine + inhibitor<br />
-
**[[6qxl]] – PyK + malonate + glucose-6-phosphate + Mg – ''Pseudomonas aerugnosa''<br />
+
**[[6qxl]] – PaPyK + malonate + glucose-6-phosphate + Mg<br />
 +
**[[6ksh]] – PfPyK + oxalate + ATP <br />
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**[[8iax]] - SpPyK + fructose bisphosphate + phosphoenolpyruvate<br />
 +
**[[8iau]] - SpPyK + fructose bisphosphate + oxalate<br />
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

3D structures of pyruvate kinase

Updated on 05-October-2023


Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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