8h38

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'''Unreleased structure'''
 
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The entry 8h38 is ON HOLD until Paper Publication
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==Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex==
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<StructureSection load='8h38' size='340' side='right'caption='[[8h38]], [[Resolution|resolution]] 4.25&Aring;' scene=''>
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Authors: Hu, Y., Mao, Q., Chen, Z., Sun, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8h38]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H38 FirstGlance]. <br>
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Description: Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.25&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Chen, Z]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h38 OCA], [https://pdbe.org/8h38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h38 RCSB], [https://www.ebi.ac.uk/pdbsum/8h38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h38 ProSAT]</span></td></tr>
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[[Category: Hu, Y]]
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</table>
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[[Category: Mao, Q]]
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== Function ==
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[[Category: Sun, L]]
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[https://www.uniprot.org/uniprot/CSN1_HUMAN CSN1_HUMAN] Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.<ref>PMID:9535219</ref> <ref>PMID:11285227</ref> <ref>PMID:11337588</ref> <ref>PMID:12732143</ref> <ref>PMID:12628923</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen Z]]
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[[Category: Hu Y]]
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[[Category: Mao Q]]
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[[Category: Sun L]]

Revision as of 05:58, 11 October 2023

Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex

PDB ID 8h38

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