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8h3q

From Proteopedia

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m (Protected "8h3q" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8h3q is ON HOLD
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==Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex==
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<StructureSection load='8h3q' size='340' side='right'caption='[[8h3q]], [[Resolution|resolution]] 3.76&Aring;' scene=''>
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Authors: Hu, Y., Mao, Q., Chen, Z., Sun, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8h3q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H3Q FirstGlance]. <br>
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Description: Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.76&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Hu, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h3q OCA], [https://pdbe.org/8h3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h3q RCSB], [https://www.ebi.ac.uk/pdbsum/8h3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h3q ProSAT]</span></td></tr>
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[[Category: Chen, Z]]
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</table>
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[[Category: Mao, Q]]
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== Function ==
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[[Category: Sun, L]]
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[https://www.uniprot.org/uniprot/CAND1_HUMAN CAND1_HUMAN] Enhances transcription from various types of promoters (By similarity). Regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. Prevents neddylation of CUL1 by physically blocking access to the neddylation site. Disrupts interactions between CUL1 and SKP1 and between CUL1 and F-box proteins.<ref>PMID:12504026</ref> <ref>PMID:12504025</ref> <ref>PMID:12609982</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen Z]]
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[[Category: Hu Y]]
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[[Category: Mao Q]]
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[[Category: Sun L]]

Revision as of 05:58, 11 October 2023

Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex

PDB ID 8h3q

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