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6do1

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==Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8==
==Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8==
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<StructureSection load='6do1' size='340' side='right' caption='[[6do1]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='6do1' size='340' side='right'caption='[[6do1]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6do1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DO1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6do1]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DO1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.901&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6do1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6do1 OCA], [http://pdbe.org/6do1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6do1 RCSB], [http://www.ebi.ac.uk/pdbsum/6do1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6do1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6do1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6do1 OCA], [https://pdbe.org/6do1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6do1 RCSB], [https://www.ebi.ac.uk/pdbsum/6do1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6do1 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/AGTR1_HUMAN AGTR1_HUMAN]] NON RARE IN EUROPE: Essential hypertension;Renal tubular dysgenesis of genetic origin. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/AGTR1_HUMAN AGTR1_HUMAN] NON RARE IN EUROPE: Essential hypertension;Renal tubular dysgenesis of genetic origin. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AGTR1_HUMAN AGTR1_HUMAN]] Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/AGTR1_HUMAN AGTR1_HUMAN] Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6do1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6do1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kruse, A C]]
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[[Category: Escherichia coli]]
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[[Category: Lefkowitz, R J]]
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[[Category: Homo sapiens]]
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[[Category: McMahon, C]]
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[[Category: Large Structures]]
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[[Category: Staus, D P]]
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[[Category: Synthetic construct]]
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[[Category: Wingler, L M]]
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[[Category: Kruse AC]]
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[[Category: Gpcr]]
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[[Category: Lefkowitz RJ]]
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[[Category: Membrane protein]]
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[[Category: McMahon C]]
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[[Category: Nanobody]]
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[[Category: Staus DP]]
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[[Category: Synthetic antibody]]
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[[Category: Wingler LM]]

Current revision

Structure of nanobody-stabilized angiotensin II type 1 receptor bound to S1I8

PDB ID 6do1

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